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Structural Biology Spin-out Tackles Major Diseases

A spin out company from basic structural biology, Asterion Ltd., has led to new technology that provides a way of creating therapeutic proteins to tackle major diseases such as cancer, diabetes and infertility.

Structural biology spin-out tackles major diseases

A spin out company from basic structural biology, Asterion Ltd., has led to new technology that provides a way of creating therapeutic proteins to tackle major diseases such as cancer, diabetes and infertility. The research was carried out at the University of Sheffield in laboratories supported by the Biotechnology and Biological Sciences Research Council (BBSRC). This work is reported in the current edition of BBSRC Business, the quarterly research highlights magazine of the Biotechnology and Biological Sciences Research Council.

PNA versus DNA: Effects of Structural Fluctuations on Electronic Structure and Hole-Transport Mechanisms

The effects of structural fluctuations on charge transfer in double-stranded DNA and peptide nucleic acid (PNA) are investigated. A palindromic sequence with two guanine bases that play the roles of hole donor and acceptor, separated by a bridge of two adenine bases, was analyzed using combined molecular dynamics (MD) and quantum-chemical methods. Surprisingly, electronic structure calculations on individual MD snapshots show significant frontier orbital electronic population on the bridge in ~10% of the structures. Electron-density delocalization to the bridge is found to be gated by fluctuations of the covalent conjugated bond structure of the aromatic rings of the nucleic bases. It is concluded, therefore, that both thermal hopping and superexchange should contribute significantly to charge transfer even in short DNA/PNA fragments.

Coherence Spectroscopy Investigations of the Low-Frequency Vibrations of Heme: Effects of Protein-Specific Perturbations

Page 5242. The normal coordinate structural decomposition (NSD) calculations in this paper had an error in the calculation of the absolute scale of the mass-weighted displacements determined from the X-ray structures. As a result, the horizontal axis of Figure 10 should be corrected as shown below. The conclusions in the paper, based on relative changes of the NSD-determined structural distortions, remain unchanged.

Structural 'snapshots' of a protein implicated in Alzheimer's disease

Figure 1: Schematic depicting generation of Aβ from APP. γ-secretase is another enzyme involved in the process. AD, Alzheimer’s disease.

Structural 'snapshots' of a protein implicated in Alzheimer's disease

(Nanowerk News) A recent study describes the structure of the active form of BACE1, which is an enzyme implicated in Alzheimer’s disease. BACE1 cleaves amyloid precursor protein (APP), thereby releasing amyloid β peptide (Aβ), the primary component of amyloid plaques found in the brains of patients with Alzheimer’s disease.

[PERSPECTIVES] STRUCTURAL BIOLOGY: Symmetric Transporters for Asymmetric Transport

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eBay's Evolution: Structural Growth Toppled By A Crumbling Foundation?

Timbo on Google Chrome: EULA Backpeddles, Additional Vulnerabilities, O/S Alternatives And More Giggles

New Scripps Research Study Solves Structural Mystery of Cellular Protein Transport

Scientists at The Scripps Research Institute have determined the structure of the protective protein coat surrounding intracellular vesicles or sacs that are needed to transport proteins out of the cell. Understanding this structure could shed critically needed light on many loss-of-function diseases such as atherosclerosis, diabetes, obesity and cystic fibrosis and lead to potential new therapies.

Bilayer in Small Bicelles Revealed by Lipid'Protein Interactions Using NMR Spectroscopy

Department of NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Go

Nanotechnology Pioneer Sells off Proprietary Line of Microfine Titanium Dioxide

Instron - Materials testing, tensile, compression, flexural, impact, structural, hardness, fatigue, testing of materials and components.

Scientists find 'redesigned hammer' that forged evolution of pregnancy in mammals

Gunter Wagner: "Transcription factors can play an active role in the origin and evolution of structural innovations. "

Statement from the Michigan Department of Transportation Regarding Accident at Gateway Construction Site

on the Michigan Department of Transportation (MDOT) I-75 Ambassador Bridge Gateway Project. The worker was an employee of Ace Structural Steel Erection, Inc. of

Statement from the Michigan Department of Transportation Regarding Accident at Gateway Construction Site

on the Michigan Department of Transportation (MDOT) I-75 Ambassador Bridge Gateway Project. The worker was an employee of Ace Structural Steel Erection, Inc. of

The Holes in Our Genomes

Hole-y DNA: Gene microarrays (shown above) designed to measure two different kinds of genetic variation--single-base changes and larger structural variations--are shedding new light on the genetic basis of complex disease.

Ahead of the Bell: Analyst keeps eBay at 'Sell' [XFNA]

NEW YORK (AP) - Shares of eBay Inc. could trade lower on Monday, after an analyst said the online auction operator has structural problems that could hurt full-year results and reiterated his "Sell" rating on the stock.

Ahead of the Bell: Analyst keeps eBay at 'Sell'

NEW YORK (AP) -- Shares of eBay Inc. could trade lower on Monday, after an analyst said the online auction operator has structural problems that could hurt full-year results and reiterated his "Sell" rating on the stock.

Powerful X-ray captures molecular shape-shifting

A haemoglobin molecule changes over a few microseconds from a "relaxed" form that can bond to oxygen, to a "tense" form that squeezes out the oxygen. Regions involved in structural changes are highlighted red (Image: Nature)

Earthquake strongly jolts "lucky" Los Angeles

LOS ANGELES (Reuters) - An earthquake struck just east of Los Angeles on Tuesday, rocking tall buildings and rattling nerves across Southern California, but causing no serious injuries or major structural damage.

Fibrous Proteins in Medical Technology

As many sectors of medical technology move away from traditional metals and plastics towards more sophisticated materials derived from supramolecular chemistry, some of the principles developed by nature’s best engineering materials are being borrowed. Discussed here are the structural characteristics of fibrous proteins.

The Guggenheim Museum Gets a Face-Lift

The Guggenheim Museum revealed it’s newly restored exterior last night after a three-year renovation. In 2005 the façade was covered with scaffolding and extensive repairs were made to Frank Lloyd Wright’s 1959 iconic design, including restoring structural steel, filling cracks in the concrete surface and repainting. To celebrate the building’s face-lift, artist Jenny Holzer projected large-scale text of her poems and writings on the building’s façade. The public art installation will continue every Friday night through December 31st. (Edward Dai/Epoch Times)

First glimpse of a key DNA repair protein at work

Mre11 proteins initiate the repair of double-strand breaks in DNA either on two ends of broken DNA brought together (synaptic complex at left) or at the site of a collapsed fork in replicating DNA (branching complex at right). The detailed structural ...

Google Android Delayed Until 2009: Google Saga Continues

The latest round of emotion comes over reports -- yes, new ones -- that Google's mobile offering is being delayed once again. This time, a Web site called Barron's Tech Trader Daily published a note from an equity firm saying handset maker HTC is having "structural problems" integrating Android into its devices. As such, the note implies, the phones could be pushed back until early 2009. The document quotes some unnamed "contacts" as revealing the news.

Goldilocks, X-rays, and Nanotechnology

X-rays - electromagnetic radiation with wavelengths that are typically of the order of 0.05 nm to 1 nm - are finding growing importance in nanoscale measurement technology and metrology. Their sub-nanometer wavelengths and their typical weak interactions with solids make X-ray probes a nearly ideal way of studying the structural characteristics of thin layer and nanoscaled structures that underlie much of modern nanotechnology. The fact that the probing wavelength is commensurate with the sizes of nanostructured objects results in interactions (in particular, scattering processes) that occur over practically measureable length and angular scales.

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