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Time-Resolved RNA SHAPE Chemistry

Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) chemistry yields quantitative RNA secondary and tertiary structure information at single nucleotide resolution. SHAPE takes advantage of the discovery that the nucleophilic reactivity of the ribose 2′-hydroxyl group is modulated by local nucleotide flexibility in the RNA backbone. Flexible nucleotides are reactive toward hydroxyl-selective electrophiles, whereas constrained nucleotides are unreactive. Initial versions of SHAPE chemistry, which employ isatoic anhydride derivatives that react on the minute time scale, are emerging as the ideal technology for monitoring equilibrium structures of RNA in a wide variety of biological environments. Here, we extend SHAPE chemistry to a benzoyl cyanide scaffold to make possible facile time-resolved kinetic studies of RNA in ~

Selective Synthesis of Co3O4 Nanocrystal with Different Shape and Crystal Plane Effect on Catalytic Property for Methane Combustion

Nanocrystal with Different Shape and Crystal Plane Effect on Catalytic Property for Methane Combustion

Custom hydrogels are shape-changing bacteria carriers

A dynamic way to alter the shape and size of microscopic three-dimensional structures built out of proteins has been developed by biological chemist Jason Shear and his former graduate student Bryan Kaehr at The Univ. of Texas at Austin.

Shuttle Endeavour's Heat Shield in Good Shape (SPACE.com)

appears to be in good shape, with engineers finding no need for an extra inspection of the spacecraft's vital heat shield, mission managers said late Monday.

ROCK BAND BRINGS FOO FIGHTERS ALBUM THE COLOUR AND THE SHAPE TO THE ROCK BAND MUSIC CATALOG OF DOWNLOADABLE CONTENT

ROCK BAND® BRINGS FOO FIGHTERS ALBUM THE COLOUR AND THE SHAPE TO THE ROCK BAND® MUSIC CATALOG OF DOWNLOADABLE CONTENT

Boron nanowires shape up to be excellent field emission nanomaterials

(Nanowerk Spotlight) Nanostructured boron and boron-related compounds have attracted considerable scientific attention to exploit their potential use in high temperature electronics, thermoelectrics, and photovoltaics due to their unique chemical and physical properties, such as chemical inertness, hardness, and adjustable energy bandgap. Boron's theoretical tubular structures may even have higher electrical conductivity than carbon nanotubes (CNTs).

Group Wants to Shape the Future of Privacy

AT&T is funding a group, called Future of Privacy, that it hopes will influence policy in the Obama administration and help set best practices for businesses' privacy policy. The groups want to provide a public forum to bring transparency to what happens to people's data on the Internet.

Experimental SPHERES Will Shape Future Spacecraft Behavior

Obviously and admittedly inspired by the Training Remotes concept (the small droid spheres that helped Luke Skywalker perfect his lightsaber skills) from Star Wars, three autonomous spheres are roaming around the International Space Station. They're even called SPHERES, but not because of an off-moment in terms of imagination for their Massachusetts Institute of Technology (MIT) developers. It actually stands for Synchronized Position Hold, Engage, Reorient, Experimental Satellites.

Cosmic Log: The shape of future elections

Quantum fluctuations in space, science, exploration and other cosmic fields... served up regularly by MSNBC.com science editor Alan Boyle since 2002.

New privacy group to shape policy

Privacy experts have banded together to influence policy in the new Obama administration and set best practices for the industry.

New Scan Detects Body Shape Under Clothes

Brown computer scientists have developed a program that creates an accurate computerized image of a person’s body even when the subject is clothed. The technology could be useful in in fashion, film, forensics, sports medicine and video gaming. Credit: Alexandru Balan, Brown University

The Olsens try to shape fashion identity

The twins Mary-Kate, left, and Ashley Olsen produce two lines of women's clothing: Elizabeth and James, and the Row.

Camp KDE 2009 Takes Shape: Presentations Announced

OStatic: "Late last week, the Camp KDE 2009 presentation selections were announced. In addition to the presentations, the meeting will feature the traditional keynote addresses and birds-of-feather meetings." Full Story...

Camp KDE 2009 Takes Shape: Presentations Announced

"The presentations that were selected are quite diverse. Some don't seem KDE-specific (such as Jeff Mitchell's presentation about why companies should hire open source programmers, and Zack Rusin's talk about graphics acceleration), while others focus on KDE and associated applications in a variety of settings (Sebastian Kugler will discuss Plasma on small formfactor devices, Orville Bennett will present on KDE and Macs, and Guillermo Antonio Amaral Bastidas will talk about KDE and business applications). The diversity in the chosen topics certainly wasn't unintentional, but it's encouraging to see this variety in the event's first year."

Camp KDE 2009 Takes Shape: Presentations Announced

Camp KDE was planned to complement Akademy, the traditional developer gathering for the KDE team, giving those unable to attend the former event (and specifically developers in the Americas) a better opportunity to gather and discuss projects. Late last week, the Camp KDE 2009 presentation selections were announced. In addition to the presentations, the meeting will feature the traditional keynote addresses and birds-of-feather meetings.

ANALYSIS - Chinese banks in good shape to pass economic test

BEIJING, Nov 24 (Reuters) - The unfolding global recession ought to resolve one of the great known unknowns about China. How will its supposedly strong banks fare when the going gets tough?

Privacy Group Hopes Hopes To Shape Policy

A newly-formed group of privacy experts are seeking to influence policy decisions of President-elect Barack Obama.

10m art gallery plan takes shape

A major funding landmark for a £10m art gallery project in south west Scotland could be reached early next year.

Greece: Eurobank Properties in great shape, says Citigroup

Eurobank Properties, looks well equipped to take advantage of distressed real estate valuations & opportunities in Greece due ot its its significant liquidity, says Citi analyst Lambros Papadopoulos.

Coal mine art project takes shape

A full planning application has been lodged to turn a former opencast coal mine into a "landscape art form".

The naked ladies in the shape of a skull from Silence of the Lambs is a reference to a Salvador Dali painting/picture.

My favorite one is typing "about:internets" in Google Chrome. (No quotes, of course.) Only works on Windows XP.

Building societies, credit unions in better shape: KPMG

Building societies and credit unions have withstood the financial crisis but will face cost pressures and a tighter margin squeeze in 2009, global consulting firm KPMG says.

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