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Mechanism Explains Link Between Apolipoprotein E And Alzheimer's Disease

Scientists have discovered a previously unknown mechanism by which apolipoprotein E, a molecule whose mutation is linked to Alzheimer's disease (AD), stimulates degradation of sticky amyloid beta (Aβ) protein within the brain. The research, published by Cell Press in the June 12 issue of the journal Neuron, may lead to a powerful new therapy for this devastating disease.

Mechanism And Function Of Humor Identified By New Evolutionary Theory

A new publication answers centuries' old questions regarding the mechanism and function of humour, identifying the reason humour is common to all human societies, its fundamental role in the evolution of homo sapiens and its continuing importance in the cognitive development of infants.

Mechanism and function of humor identified by new evolutionary theory

A new publication answers centuries' old questions regarding the mechanism and function of humour, identifying the reason humour is common to all human societies, its fundamental role in the evolution of homo sapiens and its continuing importance in the cognitive development of infants.

Discovery of gene mechanism could bring about new ways to treat metastatic cancer

Researchers identify mechanism used by therapeutically active antitumor cytokine gene able to induce potent bystander antitumor effect in cancer cells

Discovery of gene mechanism could lead to new therapeutic strategies to fight metastatic disease

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Real-time observation of the DNA-repair mechanism

For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous cells. Researchers from the Kavli Institute of Nanoscience Delft are to publish an article on this in the leading scientific journal Molecular Cell.

Real-time observation of the DNA-repair mechanism

For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous cells. Researchers from the Kavli Institute of Nanoscience Delft are to publish an article on this in the leading scientific journal Molecular Cell.

Real-time Observation Of The DNA-repair Mechanism

For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous cells.

Real-time observation of the DNA-repair mechanism

For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous cells. Researchers from the Kavli Institute of Nanoscience Delft are to publish an article on this in the leading scientific journal Molecular Cell.

Real-time observation of the DNA-repair mechanism

(Nanowerk News) For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous cells. Researchers from the Kavli Institute of Nanoscience Delft are to publish an article on this in the leading scientific journal Molecular Cell.

Michigan Inventor Develops High Performance Printing System

According to the U.S. Patent & Trademark Office: "A high performance printing system includes a paper tray for holding the blank paper prior to printing. The printer engine demands that the paper size be selected from a limited set of allowable paper sizes. A paper guide mechanism installed in the paper tray has a configuration that operates to guide a paper size having a reduced width relative to a particular allowed paper size. The paper guide mechanism allows reduced width paper to be used in the paper tray, essentially without otherwise adjusting the printing system, such that the printer engine sees the paper size as a particular allowed paper size when a reduced width paper is being used for printing."

Mechanism That Explains How Cancer Enzyme Winds Up On Ends Of Chromosomes Found

Human cancer cells divide and conquer. Unless physicians can control that division with surgery, chemotherapy or radiation, the wildly dividing cells will eventually destroy a person's life.

Study identifies mechanism linking stress to physical illness, aging

Every cell contains a tiny clock called a telomere, which shortens each time the cell divides. Short telomeres are linked to a range of human diseases, including HIV, osteoporosis, heart disease and aging. Previous studies have shown that an enzyme within the cell, called telomerase, keeps immune cells young by preserving their telomere length and ability to continue dividing. UCLA scientists found that the stress hormone cortisol suppresses immune cells' ability to activate their telomerase. This may explain why the cells of persons under chronic stress have shorter telomeres.

The Catalytic Mechanism of an Aspartic Proteinase Explored with Neutron and X-ray Diffraction

Spallation Neutron Source, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831, Department of Chemistry, University of Toledo, Toledo, Ohio 53606, Bioscience Division, Mailstop M888, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, and Laboratory for Protein Crystallography, Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London (Hampstead Campus), Rowland Hill Street, London NW3 2PF, U.K.

UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes

Human cancer cells divide and conquer. Unless physicians can control that division with surgery, chemotherapy or radiation, the wildly dividing cells will eventually destroy a person's life.

On the Molecular Mechanism of Drug Intercalation into DNA: A Simulation Study of the Intercalation Pathway, Free Energy, and DNA Structural Changes

de Lyon, 7 passage du Vercors, Lyon 69367, France, Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India, and Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215

Discovery of gene mechanism could bring about new ways to treat metastatic cancer

Virginia Commonwealth University and VCU Massey Cancer Center researchers have uncovered how a gene, melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24), induces a bystander effect that kills cancer cells not directly receiving mda-7/IL-24 without harming healthy ones, a discovery that could lead to new therapeutic strategies to fight metastatic disease.

Police don't have mechanism to tackle cyber crime

GUWAHATI, July 7 – It is official now. Contrary to what various senior Assam Police officials, including the Director General of Police (DGP), have been claiming, Assam Police does not have the firepower to tackle the menace of cyber crime.

Sunlight creates asteroids' moons by spinning mechanism

Washington, July 10 : A trio of astronomers from Maryland in the US, and France, have said that moons that revolve around asteroids (binary asteroids) are formed by sunlight, which can increase or decrease the spin rate of an asteroid.

The Inhibition of Embryonic Histone Deacetylases as the Possible Mechanism Accounting for Axial Skeletal Malformations Induced by Sodium Salicylate

The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Alzheimer's Disease: Probiodrug obtains patent on novel disease mechanism and treatment option in AD

HALLE/SAALE, Germany, June 16, 2008 -- Probiodrug AG (Probiodrug), a developer of small molecule inhibitors for the treatment of inflammatory and neurodegenerative diseases, announced today that the United States Patent Office issued to Probiodrug the US patent no. 7,381,537, the first patent covering broad methods of treating Alzheimer’s disease using compounds that inhibit mammalian glutaminyl cyclase (QC).

Spacewalkers to Investigate Russian Craft's Malfunction

A view of the locking mechanism that holds the Soyuz return and propulsion modules together. The 10 pyro bolts that fire to separate the modules are located where the structure meets to form "V" shapes. Credit: NASA

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