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Immune Response To Human Embryonic Stem Cells In Mice Suggests Human Therapy May Face Challenge

Human embryonic stem cells trigger an immune response in mice, researchers from the Stanford University School of Medicine report. The finding suggests that the effectiveness of human therapies derived from the cells could be limited unless ways are found to dampen the rejection response.

Immune Response to Human Embryonic Stem Cells in Mice Suggests Human Therapy May Face Challenge, Stanford Study Shows

Immune Response to Human Embryonic Stem Cells in Mice Suggests Human Therapy May Face Challenge, Stanford Study Shows

Cells Safely Changed into Embryonic State in Tests

Scientists are reporting they have overcome a major obstacle to using a promising alternative to embryonic stem cells, bolstering the prospects for bypassing the political and ethical tempest that has embroiled hopes for a new generation of medical treatments.

Loss Of The Protein Target Of Lithium Disrupts Normal Mouse Embryonic Heart Development

One drug used to treat bipolar disorder is lithium, an inhibitor of GSK-3 proteins controversially linked to congenital heart defects. However, new data indicate that mice lacking GSK-3-beta die before birth, mostly at the late stage of embryonic development because of numerous defects in the heart. It is therefore suggested that it might be wise to exercise caution when considering whether to treat women of childbearing age with newer, more powerful GSK-3 inhibitors.

Geron Announces Issuance of U.S. Patent for Cardiomyocytes From Human Embryonic Stem Cells

MENLO PARK, Calif.--(BUSINESS WIRE)--Sept. 16, 2008 - Geron Corporation (Nasdaq:GERN) today announced the issuance of U.S. Patent No. 7,425,448, with broad claims to cardiomyocytes derived from human embryonic stem cells (hESCs). The patent runs until at least April 2025 (subject to any patent term extension that may be available). Geron's GRNCM1 program is developing hESC-derived cardiomyocytes for the treatment of heart disease.

Safer Creation of Stem Cells

Get rid of DNA-altering viruses—check. In a crucial step toward realizing medical treatments based on embryonic-like stem cells, researchers have found a safer way to revert adult mouse cells to an embryonic state.

Safe Stem Cells Produced From Adult Cells

hackingbear writes "Wired, citing a paper published in Science magazine, reports that Harvard scientists may have found a safer way of giving a flake of skin the biologically alchemical powers of embryonic stem cells by turning adult cells into versatile, embryonic-like cells without causing permanent damage. The technique involves 'adding cell-reprogramming genes to adenoviruses, a type of virus that infects cells without affecting their DNA.' Four-month trials on mice demonstrated that the resulting stem cells are free from unpredictable cancer-inducing mutations. This is definitely a breakthrough in stem cell research." Additional coverage is available at Yahoo, and Science hosts the research paper, although you'll need a subscription to see more than the abstract.

Human Embryonic Stem Cell Secretions Minimize Tissue Injury After Heart Attack

A novel way to improve survival and recovery rate after a heart attack was reported in the journal Stem Cell Research by scientists at Singapore's Institute of Medical Biology (IMB) and Bioprocessing Technology Institute (BTI) and The Netherlands' University Medical Center Utrecht.

Human embryonic stem cell secretions minimized tissue injury after heart attack

A novel way to improve survival and recovery rate after a heart attack was reported in the journal Stem Cell Research by scientists at Singapore's Institute of Medical Biology (IMB) and Bioprocessing Technology Institute (BTI) and The Netherlands' University Medical Center Utrecht.

Despite Breakthroughs, Embryonic Stem Cells Still Needed

The transformation of pancreas cells from one type to another has been hailed as a breakthrough: until now, such tricks required of scientifically -- and sometimes ethically -- tricky stem cells.

Scientists reveal changes to embryonic stem cells caused by Down syndrome

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Stem Cell Sciences Announces the Creation of First Authentic Rat Embryonic Stem Cells

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Economy could close flap on ideas

Embryonic high-tech companies could become the latest victims of the credit crunch, according to those gathered at a conference showcasing new firms.

Putting microRNAs on the stem cell map

Embryonic stem cells are always facing a choice - either to self-renew or begin morphing into another type of cell altogether. It's a tricky choice, governed by complex gene regulatory circuitry driven by a handful of key regulators known as "master transcription factors," proteins that switch gene expression on or off.

Governor vetoes bill guaranteeing access to stem-cell therapies for poor

What is it about embryonic stem cell research that turns politicians into courtiers? Bring up Big Pharma, and the anti-greed rhetoric soars. HMOs? Just try to shut them up about heartless corporate bean-counters. Yet even though the same get-rich, money-talks ethos drives Big Biotech, government leaders trip over each other to grant its policy agendas carte blanche.

New research takes the bite out of the stem cell debate

Japanese scientists have derived ‘embryonic’ stem cells from tissue taken from discarded human wisdom teeth, potentially bypassing the ethical dilemma of taking them from embryos.

Putting microRNAs on the stem cell map

CAMBRIDGE, Mass. (August 7, 2008) – Embryonic stem cells are always facing a choice—either to self-renew or begin morphing into another type of cell altogether.

McCain Equates Embryos and Fetuses in Stem Cell Statement

John McCain's recent statement on embryonic stem cell research was ambiguous in some ways, but clearly misleading in another: He equated human embryos with fetuses, and used language implying that farming fetuses for their tissues is a realistic possibility.

Researchers Report Stem Cell Alternative

Scientists say they might have found an alternative to embryonic stem cells that would allow them to exit an ethics debate over using discarded embryos.

Researchers report stem cell alternative

Scientists say they might have found an alternative to embryonic stem cells that would allow them to exit an ethics debate over using discarded embryos.

Programmed Cell Death Contributes Force To Movement Of Cells

In addition to pruning cells out of the way during embryonic development, the much-studied process of programmed cell death, or apoptosis, has been newly found to exert significant mechanical force on surrounding cells.

First Licensed Human Embryo Clones Will Be Australian

Scientists were given green light by the Australian government, in order to obtain embryonic stem cells out of cloned human embryos. The license and 7.200 human eggs were granted to Sydney IVF, an in vitro fertilization company.

Researchers report stem cell alternative

CAMBRIDGE, Mass., Sept. 27 (UPI) -- Scientists say they might have found an alternative to embryonic stem cells that would allow them to exit an ethics debate over using discarded embryos.

Stem Cell Alchemy Refined

Scientists may have found a safer way of giving a flake of skin the biologically alchemical powers of embryonic stem cells.

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