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Eight-year Clinical Outcomes Of Enzyme Replacement Therapy In 884 Children With Type I Gaucher Disease

Gaucher disease is a rare genetic disorder that occurs when a person lacks an enzyme called glucocerebrosidase. The most common form of this disorder is type 1 Gaucher disease. Type 1 Gaucher disease can start at any age, but recently it has been shown that about half of all patients are diagnosed before 18 years of age.

Intellect Neurosciences, Inc. Validates Pivotal European Patent for Alzheimer's Monoclonal Antibody Platform

NEW YORK, November 11, 2008 /PRNewswire-FirstCall/ -- a biopharmaceutical company focused on development of disease-modifying therapeutic agents for the treatment and prevention of Alzheimer's disease (AD), announced today that it has completed validation of its European patent related to antibodies and methods of treatment for Alzheimer's disease in Germany, France, United Kingdom and the Netherlands. Validation of the patent is currently underway in other European countries. The patent also has been granted in countries outside of Europe and is pending in the United States. More than six million Europeans are affected by the disease.

New clue emerges for cellular damage in Huntington's disease

CAMBRIDGE, Mass. (November 17, 2008) "Huntington's disease presents an ideal vantage point to study neurodegenerative disease, because we know the misfolded protein that's responsible," says Martin Duennwald, formerly a postdoctoral researcher in the lab of Whitehead Member Susan Lindquist. "But we don't understand how this protein causes cellular damage and death for the neurons that are affected."

Faster Test For Food Protein That Triggers Celiac Disease

Researchers in Spain and the United Kingdom are reporting development of a faster test for identifying the food protein that triggers celiac disease, a difficult-to-diagnose digestive disease involving the inability to digest protein called gluten that occurs in wheat, oats, rye, and barley. The finding could help millions of people avoid diarrhea, bloating, and other symptoms that occur when they unknowingly eat foods containing gluten.

LSU Health Sciences Center Research Identifies Key Contributor to Alzheimer's Disease Process

NEW ORLEANS, Nov. 14 (AScribe Newswire) -- Walter J. Lukiw, PhD, Associate Professor of Neuroscience and Ophthalmology at LSU Health Sciences Center New Orleans, is the lead author of a paper identifying, for the first time, a specific function of a fragment of ribonucleic acid (RNA), once thought to be no more than a byproduct, in regulating inflammation and the development of Alzheimer's disease. The paper, An NF-kB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer's disease and in stressed human brain cells, will be published in the November 14, 2008 issue of The Journal of Biological Chemistry.

Foot and Mouth Disease Vaccines - Scientists at China Agricultural University, College of Biological Science describe research in foot and mouth disease vaccines

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Alzheimer's Gene Slows Brain's Ability to Export Toxic Protein

The only known genetic risk factor for Alzheimer’s disease slows down the brain’s ability to export a toxic protein known as amyloid-beta that is central to the damage the disease causes, scientists have found. The research, published by the Journal of Clinical Investigation, provides new clues into the workings of a protein known as apolipoprotein E4, or ApoE4. People who carry two copies of the gene have roughly eight to 10 times the risk of getting Alzheimer’s disease than people who do not.

Nanotechnology improves food safety by detecting prions

(Farm Talk Newspaper (Parsons, Kan.) Via Acquire Media NewsEdge) Oct. 29--Mad cow disease is a fatal neurodegenerative condition in cattle that is related to the human form of a disease that has caused the deaths of nearly 200 people worldwide. Currently, testing for this disease in cattle is a lengthy process that only occasionally results in a correct diagnosis.

Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes

BOSTON, October 30, 2008 /PRNewswire-USNewswire/ -- Four novel genes that may significantly increase the risk of the most common form of late-onset Alzheimer's have been identified by researchers at Massachusetts General Hospital and , as reported in the November 7th issue of The findings, part of a larger "Alzheimer's Genome Project" (AGP) established three years ago to identify the full set of Alzheimer's disease genetic risk factors, may lead to more aggressive therapeutic interventions to slow, stop or even reverse the effects of the disease. These new therapies would differ from current treatments that only address the symptoms of the disease.

Breakthrough Mapping Of Alzheimer's Genome Helps ID Four New Suspect Genes

Four novel genes that may significantly increase the risk of the most common form of late-onset Alzheimer's have been identified by researchers at Massachusetts General Hospital and Harvard Medical School, as reported in the November 7th issue of American Journal of Human Genetics. The findings, part of a larger "Alzheimer's Genome Project" (AGP) established three years ago to identify the full set of Alzheimer's disease genetic risk factors, may lead to more aggressive therapeutic interventions to slow, stop or even reverse the effects of the disease. These new therapies would differ from current treatments that only address the symptoms of the disease.

Disease Can Cause Extinction of Mammals

Disease can drive a mammal species to extinction: this doesn't seem surprising, but until today it hadn't been proven. And now that it has, members of our own mammalian species might understandably feel uneasy.

Revolutionary disease detection combines Nature's diagnostic tools with nanotechnology and electronics

Revolutionary disease detection combines Nature's diagnostic tools with nanotechnology and electronics

Google Flu: Internet disease tracker aims to save thousands from killer - Exclusive

The internet search giant aims to flag up disease blackspots by collating millions of searches for medicines by sufferers.

Google helps fight disease

WASHINGTON: Google is, for the first time, putting its massive data-collecting power on the Web to work in combating disease.

Stem cell therapies for heart disease -- 1 step closer

New research from the University of Bristol brings stem cell therapies for heart disease one step closer. The findings reveal that our bodies' ability to respond to an internal 'mayday' signal may hold the key to success for long-awaited regenerative medicine.

Induction Of Pgc-1 Alpha Expression In Huntington's Disease Transgenic Mice Rescues Neuronal Dysfunction And Neurodegeneration

Neurodegenerative diseases pose a considerable burden to our aging population. Huntington's disease (HD) is an inherited neurological disorder that affects as many as 40,000 people in the U.S. alone. HD causes degeneration of the brain, which results in involuntary movement disorder, cognitive decline, and ultimately death.

Scientists demonstrate mammal extinction due to disease

Scientists have claimed that diseases carried by Eurasian black rats caused the rapid extinction of Christmas Island native rats - the first study to demonstrate extinction in a mammal because of disease.

Is blogging like a sexually transmitted disease?

Watch this hilarious clip from last night’s The Daily Show. Arianna Huffington calls for the retrenched and depressed to write for her: it’s therapeutic. She also tells Jon Stewart, her favourite embeddable, that 50 000 blogs are started a day, to which Stewart says “You make it sound like a sexually transmitted disease?�

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