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Lytic Transglycosylase MltB of Escherichia coli and Its Role in Recycling of Peptidoglycan Strands of Bacterial Cell Wall

The cell wall is an indispensable structure for the survival of bacteria and a target for antibiotics. Peptidoglycan is the major constituent of the cell wall, which is comprised of backbone repeats of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM). A peptide stem is appended to the NAM unit, which in turn experiences cross-linking with a peptide from another peptidoglycan in the final steps of cell wall assembly. In the normal course of bacterial growth, as much as 60% of the parental cell wall is recycled, a process that is not fully understood. A polymeric cell wall is fragmented by the family of lytic transglycosylases, and certain key fragments are transported to the cytoplasm for recycling. The genes for the six known lytic transglycosylases of Escherichia coli were cloned, and the enzymes were purified in this study.

Scientists create 20 disease-specific stem cell lines

(PhysOrg.com) -- Harvard Stem Cell Institute researcher George Q. Daley, associate director of the Stem Cell Program at Children's Hospital Boston, has with HSCI colleagues Chad Cowan and Konrad Hochedlinger of Massachusetts General Hospital produced a robust new collection of disease-specific stem cell lines, all of which were developed using the new induced pluripotent stem cell (iPS) technique. The work is described in a paper published in today's online edition of the journal Cell.

Daley and colleagues create 20 disease-specific stem cell lines

Boston, Mass, Aug. 7, 2008 – Harvard Stem Cell Institute researcher George Q. Daley, MD, PhD, also associate director of the Stem Cell Program at Children's Hospital Boston, and HSCI colleagues Konrad Hochedlinger and Chad Cowan have produced a robust new collection of disease-specific stem cell lines, all of which were developed using the new induced pluripotent stem cell (iPS) technique. The paper is being published in the August 6 on-line edition of the journal Cell.

University of Queensland teams up with Chinese Academy of Sciences for Fuel Cell R&D

Fuel Cell Today - Informing the fuel cell industry. Fuel Cell Today provides market based intelligence on the fuel cell industry, including surveys, news, images and investment information.

Major Stem Cell Breakthrough

(Nanowerk News) Minerva Biotechnologies, a leading nanotechnology, cancer and stem cell development company today announced a major breakthrough in stem cell research. Minerva and collaborators at the University of California at Santa Barbara discovered that a single, new growth factor can not only support massive growth of human embryonic stem cells (hESCs) in vitro, but also maintains them in a nearly 100% undifferentiated state without the need for fibroblast "feeder cells". This represents a major step forward for potential stem cell therapies as well as in the basic understanding of the mechanisms that regulate stem cell growth and differentiation.

Digital Camera Powered By a Fuel Cell

An anonymous reader notes a development from the world of photography that could spread to notebooks and cell phones. Canon has filed for a patent on a fuel cell powered DSLR. The fuel cell would power not only the camera body but also all accessories attached to it, doing away with the need to power flashes (for example) with AA or other batteries. The patent covers other electronic devices generally, but is clearly directed toward DSLR cameras, given the diagrams and examples used. "Canon continues to push its fuel cell development by devising a method for powering not only the internal DSLR body electronics, but also external components such as lenses and hotshoe flashes."

Thermo Fisher Scientific Launches Versatile New System For Production-Scale Cell Culture

Thermo Fisher Scientific Inc., the world leader in serving science, today introduced the new Thermo Scientific Nunc EasyFill Cell Factory, an easy-to-use multi-layer system for production-scale cell culture. The versatile Nunc EasyFill Cell Factory features two options for filling and harvesting. The traditional port enables aseptic filling through tubing connections while the large port facilitates the pouring of media directly into the Cell Factory system. The dual port design supports process transfer and scale up, from research applications through commercial production.

Stem Cell Therapeutics Corp. (Calgary, AB)

Stem Cell Therapeutics Corp. (Calgary, AB) announces that it has been granted U.S. patent no. 7,393,830 entitled “Prolactin induced increase in neural stem cell numbers�, and Australian patent no. 2002325711 entitled “Prolactin induced increase in neural stem cell numbers and therapeutical use thereof�. These patents cover the use of prolactin alone, as well as in combination with other therapeutics. Prolactin is used alone or with anti-inflammatories in programs to treat multiple sclerosis, and in combination with EPO to treat neurodegenerative diseases.

Muscle Stem Cell Identity Confirmed By Researchers

A single cell can repopulate damaged skeletal muscle in mice, say scientists at the Stanford University School of Medicine, who devised a way to track the cell's fate in living animals. The research is the first to confirm that so-called satellite cells encircling muscle fibers harbor an elusive muscle stem cell.

Location Sensitivity - Cell Phone GPS

Location Sensitivity, Cell Phone GPS - Prudent Press Agency (Prudent Press Agency)---This is basically a system to locate the handheld when making a call to 911. In the mid to late 1990's, many people got cell phones just for the emergency use of being able to call for help almost anywhere. The problem came up when statistics showed that almost 92% of all serious 911 calls, (where the person was just barely able to make the call), they either didn't know where they were or was unable to tell the 911 operator where they were, or they might not have been able to talk at all. This caused a big concern, 911 operators couldn't do anything but listen to the person on their cell phone as they pass away. The Location Sensitivity system still doesn't work if you are in an area that only has an analog signal.

New Solar Cell Sets World Efficiency Record

asoduk writes to tell us that a new world record has been set for the most efficient photovoltaic device. Topping the scale at 40.8% efficiency, the new solar cell differs significantly from the previous record holder. "Instead of using a germanium wafer as the bottom junction of the device, the new design uses compositions of gallium indium phosphide and gallium indium arsenide to split the solar spectrum into three equal parts that are absorbed by each of the cell's three junctions for higher potential efficiencies. This is accomplished by growing the solar cell on a gallium arsenide wafer, flipping it over, then removing the wafer. The resulting device is extremely thin and light and represents a new class of solar cells with advantages in performance, design, operation and cost.

VIASPACE Reports That Key Fuel Cell Patent in Europe, Licensed by VIASPACE Subsidiary, Has Been Issued to Caltech

PASADENA, Calif., Sept. 8 /PRNewswire-FirstCall/ -- VIASPACE Inc. , announced today that a key Caltech direct methanol fuel cell patent was granted in Europe, specifically Germany, Spain, France, Great Britain, Italy, Netherlands and Sweden. This is patent EP 0 755 576 B1 for an organic fuel cell and methods of operation thereof and methods of manufacture thereof. The patent has been licensed from Caltech and the University of Southern California by VIASPACE subsidiary, Direct Methanol Fuel Cell Corporation (DMFCC).

7th-Grader Designs Three Dimensional Solar Cell

Hugh Pickens writes "12-year-old William Yuan's invention of a highly-efficient, three-dimensional nanotube solar cell for visible and ultraviolet light has won him an award and a $25,000 scholarship from the Davidson Institute for Talent Development. 'Current solar cells are flat and can only absorb visible light'" Yuan said. 'I came up with an innovative solar cell that absorbs both visible and UV light. My project focused on finding the optimum solar cell to further increase the light absorption and efficiency and design a nanotube for light-electricity conversion efficiency.' Solar panels with his 3D cells would provide 500 times more light absorption than commercially-available solar cells and nine times more than cutting-edge 3D solar cells.

Time Of Day Influences Yield For Pharmacologically Stimulated Stem Cell Mobilization

A new study uncovers a previously unrecognized, species-specific impact of circadian rhythms on the production of mobilized stem cells. The research, published by Cell Press in the October 9th issue of the journal Cell Stem Cell, suggests that when it comes to collecting human stem cells for clinical transplantation, picking the right time of day to harvest cells may result in a greater yield.

Time of day influences yield for pharmacologically stimulated stem cell mobilization

A new study uncovers a previously unrecognized, species-specific impact of circadian rhythms on the production of mobilized stem cells. The research, published by Cell Press in the October 9th issue of the journal Cell Stem Cell, suggests that when it comes to collecting human stem cells for clinical transplantation, picking the right time of day to harvest cells may result in a greater yield.

New Stem Cell Screening Tool Takes Adult Stem Cell Research To New Level

Stem cell research is the next great leap in medicine. In the future, new tissue grown in a laboratory could replace a failing heart, or new cells take the place of damaged cells in the brain.

Whats Hot in Green Patents Wind Power and Fuel Cells

Fuel Cell Today - Informing the fuel cell industry. Fuel Cell Today provides market based intelligence on the fuel cell industry, including surveys, news, images and investment information.

Characterization of Tight Junction Proteins in Cultured Human Urothelial Cells

Abstract Tight junctions (TJs) are essential for normal function of epithelia, restricting paracellular diffusion and contributing to the maintenance of cell surface polarity. Superficial cells of the urothelium develop TJs, the basis for the paracellular permeability barrier of the bladder against diffusion of urinary solutes. Focusing on the superficial cell layer of stratified cell cultures of an immortalized human ureteral cell line, TEU-2 cells, we have examined the presence of TJ and TJ-associated proteins. TEU-2 cells were treated with calcium chloride and fetal bovine serum culture conditions used to induce stratification that resembles the normal transitional epithelial phenotype. Cultures were examined for TJ and TJ-associated proteins by confocal immunofiuorescence microscopy and evaluated for TJ mRNA by reverse transcriptase-p

Cell Chip Coming To the PC Via a PCI Express Card

arcticstoat writes with an excerpt from Custom PC: "After developing a brand new CPU architecture from the ground-up, you'd expect that Toshiba, Sony and IBM would have more uses for the Cell architecture than the PlayStation 3, and Toshiba has been quick to make use of the architecture's HD video transcoding abilities in its new Qosimo laptops. However, Leadtek is now taking Toshiba's efforts a step further by putting the chip onto a PCI-E card for desktop PCs. The WinFast PxVC1100 is based on Toshiba's SpursEngine SE1000 processor, which is a cut-down version of the Cell chip. The SpursEngine chip features four SPEs (synergistic processing elements) based on 128-bit RISC cores, along with H.264 and MPEG-2 codecs, but it doesn't contain its own CPU as the chip in the PS3 does.

Stem Cell Therapeutics Announces Issuance of Australian Patent

Stem Cell Therapeutics Corp. ("SCT") (TSX VENTURE:SSS) has been issued Australian Patent No. 2003250697, entitled "Oligodendrocyte Production from Multipotent Neural Stem Cells". This patent, issued on August 14, 2008, covers methods of producing oligodendrocytes from neural stem cells using granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin 3 (IL-3), or interleukin 5 (IL-5), either in vivo or in cell culture, as well as oligodendrocyte compositions produced by such methods. This is the first patent to issue in this patent family.

Stem Cell Therapeutics Announces Issuance of Australian Patent

Stem Cell Therapeutics Corp. ("SCT") (TSX VENTURE: SSS) has been issued Australian Patent No. 2003250697, entitled "Oligodendrocyte Production from Multipotent Neural Stem Cells". This patent, issued on August 14, 2008, covers methods of producing oligodendrocytes from neural stem cells using granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin 3 (IL-3), or interleukin 5 (IL-5), either in vivo or in cell culture, as well as oligodendrocyte compositions produced by such methods. This is the first patent to issue in this patent family.

New Cell Fate Determination Process Found

U.S. scientists have found a new mechanism for cell fate determination -- how one cell can differ from another despite having the same genetic material.

New cell fate determination process found

U.S. scientists have found a new mechanism for cell fate determination -- how one cell can differ from another despite having the same genetic material.

Cell Phone is 25-years old today: first handset was $3,995

It is hard to think that the cell phone is actually 25-years old today; the very first cell phone call was made back on October 13, 1983. Bob Barnett, the president of Ameritech Mobile communications made a phone call to Alexander Graham Bell’s nephew from Chicago’s Soldier Field.

New cell fate determination process found

EVANSTON, Ill., Aug. 20 (UPI) -- U.S. scientists have found a new mechanism for cell fate determination -- how one cell can differ from another despite having the same genetic material.

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