Interstrand Cross Link Formation in Duplex and Triplex DNA by Modified Pyrimidines: related news

Interstrand Cross-Link Formation in Duplex and Triplex DNA by Modified Pyrimidines

Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218 and Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224

Genetic link between Crohn's and asthma discovered

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A global DNA barcode database

Add our medical news to digg - A global DNA barcode database Add our medical news to NewsVine - A global DNA barcode database Add our medical news to Fark - A global DNA barcode database Add our medical news to Furl - A global DNA barcode database Add our medical news to Shadows - A global DNA barcode database Add our medical news to YahooMyWeb - A global DNA barcode database Add our medical news to Reddit -A global DNA barcode database Add our medical news to StumbleUpon - A global DNA barcode database Add our medical news to Facebook - A global DNA barcode database

Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini

We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5′- and 3′-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

Formation of Tricyclic [4.3.3.0] Adducts between 8-Oxoguanosine and Tyrosine under Conditions of Oxidative DNA'Protein Cross-Linking

Formation of Tricyclic [4.3.3.0] Adducts between 8-Oxoguanosine and Tyrosine under Conditions of Oxidative DNA−Protein Cross-Linking

Modified DNA helps scientists understand secrets of DNA repair mechanisms

(Nanowerk News) A modified DNA is helping scientists to understand the sophisticated DNA repair mechanisms that allow dormant bacteria to come 'back to life'.

Self-Promoted DNA Interstrand Cross-Link Formation by an Abasic Site

Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218

First DNA Molecule Constructed from Mostly Synthetic Components

ScienceDaily is reporting that Japanese chemists have created the world's first DNA molecule comprised of almost entirely artificial components. The breakthrough could lead to advances in both medicine and technology, possibly utilizing the massive storage capacity of DNA. "In the new study, Masahiko Inouye and colleagues point out that scientists have tried for years to develop artificial versions of DNA in order to extend its amazing information storage capabilities. As the genetic blueprint of all life forms, DNA uses the same set of four basic building blocks, known as bases, to code for a variety of proteins used in cell functioning and development. Until now, scientists have only been able to craft DNA molecules with one or a few artificial parts, including certain bases.

DNA Heritage Success in Patent Battle Helps Keep Genealogy DNA Test Prices Low

PRNewswire/ -- DNA Heritage has recently overcome patent claims held by a competitor which would have severely restricted the use of DNA testing and databases that allow families around the world to match and connect up through their DNA. The patent covers the use of surnames and Y-chromosomes to establish a family connection. The UK Intellectual Property Office (UK IPO) has now rendered a formal opinion stating that the relevant claims are all invalid.

DNA Heritage Success in Patent Battle Helps Keep Genealogy DNA Test Prices Low

RICHMOND, Texas, July 30 /PRNewswire/ -- DNA Heritage has recently overcome patent claims held by a competitor which would have severely restricted the use of DNA testing and databases that allow families around the world to match and connect up through their DNA. The patent covers the use of surnames and Y-chromosomes to establish a family connection. The UK Intellectual Property Office (UK IPO) has now rendered a formal opinion stating that the relevant claims are all invalid.

Miniaturized DNA Sewing Machines

Roland Piquepaille writes "Japanese researchers have found a way to build long threads of DNA using miniaturized hooks and bobbins. In fact, they've demonstrated how to manipulate delicate DNA chains without breaking them. They've designed these laser-directed microdevices to pick up and manipulate individual molecules of DNA. The scientists have used optical tweezers to catch and move these microdevices, which could be used in the future to detect genetic disorders such as Down's syndrome." Here's a link to the journal article.

New electrostatic-based DNA microarray technique could revolutionize medical diagnostics

A new method for reading DNA (or RNA) microarrays is based on measuring the electrostatic repulsion between silica microspheres and hybridized DNA. Surface areas containing double-stranded DNA (red) or single-stranded DNA (blue) can be easily disting ...

Gap between domestic and cross-border e-commerce grows wider, says EU report

EU Consumer Commissioner Meglena Kuneva today announced the results of a new EU wide survey on e-commerce and cross border trade. The figures show that even though e-commerce is taking off at national level, cross-border e-commerce is failing to keep pace. From 2006 to 2008, the share of all EU consumers that have bought at least one item over the internet has increased significantly (from 27% to 33%) whilst cross border e-commerce is stable (6% to 7%). The pattern is similar for those with internet access at home - 56% of consumers with internet at home have made a purchase (in any country including their own) by e-commerce compared to 50% in 2006, while only 13% (of those with internet access at home) made a cross-border e-commerce purchase compared to 12% in 2006.

Don't You Feel Safer Now That Google Added A Link To Its Privacy Policy?

One of the more idiotic accusations thrown at Google of late was this idea that it was somehow a problem that it didn't link directly to its privacy policy from its home page. It had a privacy policy. That privacy policy was easy to find. Almost no one actually reads its privacy policy -- but a bunch of privacy groups who surely had more important things to spend their time on got all upset that Google refused to link from its front page. It appears that Google has now given in and agreed to link to the privacy policy, oddly removing the word "Google" from its copyright notice and replacing it with a link to the privacy policy.

DNA Sewing Machine Manipulates Delicate DNA Chains Without Breaking Them

Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The new work demonstrates a unique way to manipulate delicate DNA chains without breaking them.

Researchers Find Link Between DNA Palindromes and Disease

Long DNA sequences, or palindromes, change the shape of the molecule from double helix to hairpin-like formation, which causes replication to stall. Altered or stalled replication causes chromosomal breaking, resulting in cancers and diseases.

Electron Transport by Molecular Motion of redox-DNA Strands: Unexpectedly Slow Rotational Dynamics of 20-mer ds-DNA Chains End-Grafted onto Surfaces via C6 Linkers

Electron Transport by Molecular Motion of redox-DNA Strands: Unexpectedly Slow Rotational Dynamics of 20-mer ds-DNA Chains End-Grafted onto Surfaces via C

Discovering the secrets of DNA repair

A modified DNA is helping scientists to understand the sophisticated DNA repair mechanisms that allow dormant bacteria to come 'back to life'.

DNA sewing machine

(Nanowerk News) Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The work published in the Royal Society of Chemistry journal Lab on a Chip demonstrates a unique way to manipulate delicate DNA chains without breaking them ("On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures" – free access article).

D-Link Now Shipping Wi-Fi Digital Photo Frame; Makes Internet Uploads a Snap

FOUNTAIN VALLEY, CA, Jul 09 (MARKET WIRE) -- D-Link today announced that it is now shipping the new Wi-Fi digital photo frame that lets users quickly and effortlessly display and share photos, as well as popular Internet content, using a convenient website or with a drag and drop widget. The D-Link(R) 10" Wireless Internet Photo Frame (DSM-210) combines the benefits of a digital photo frame with the convenience of the Internet, letting users easily manage digital photos stored on their computer or photo sharing website such as Flickr(R), Picasa(R) and Facebook(R). The D-Link frame also enables streaming of Internet content directly to the frame such as news, weather, sports, trivia, and Really Simple Syndication (RSS) feeds without the need to connect with a PC.

Researchers Discover New DNA Binding Activity of E. coli Protein

Northeastern University scientists have discovered a new and unique DNA binding property of a protein in E. coli. Penny J. Beuning, Assistant Professor in the Department of Chemistry and Chemical Biology, spent the last two years researching double and single-stranded DNA binding of E. coli DNA polymerase III alpha protein and notes that her findings have potential for developing a new antibacterial target.

Google Adds Privacy Policy Link

After a month of pressure from privacy groups, search engine Google has finally agreed to add a link on its homepage to the company's privacy policy. Google had resisted the addition of a privacy link, saying it did not want to clutter its homepage. "We're making a homepage change by adding a link to our privacy overview and policies," Marissa Mayer, vice president of Search Products & User Experience, said in a July 3 Google Blog post. "Google values our users' privacy first and foremost. Trust is the basis of everything we do, so we want you to be familiar and comfortable with the integrity and care we give your personal data."

Zetasizer Nano helps establish size independence in DNA driven nanoparticle structuring

A research team led by Dr Oleg Gang at the Brookhaven Center for Functional Nanomaterials (CFN) in New York is using the Zetasizer Nano particle characterization system from Malvern Instruments in ground-breaking work that has demonstrated successful DNA-guided formation of ordered 3-D crystalline structures. DNA's natural ability to self-assemble according to pre-programmed genetic codes within its pairing bases makes it the perfect architectural device for construction of novel crystalline structures. The ability to engineer such 3-D structures enables the production of functional materials that take advantage of the unique properties that may exist at the nanoscale - for example, enhanced magnetism, improved catalytic activity, or new optical properties.

On the Effect of Low-Energy Electron Induced DNA Strand Break in Aqueous Solution: A Theoretical Study Indicating Guanine as a Weak Link in DNA

In this theoretical study we have investigated the effect of low-energy electrons attached onto a 3′-guanine monophosphate, 3′-GMP, in the gas phase and in aqueous solution. DFT calculations with B3LYP/DZP++ were performed to study the C3′−O3′ bond break of a 3′-GMP radical anion. Our results show that low-energy electrons, if attached to a 3′-GMP with a neutrally charged phosphate group, can easily induce a C3′−O3′ bond break in both the gas phase and aqueous solution. The activation energy was found here to be 10.3 kcal/mol in the gas phase and, even lower, 5.3 kcal/mol in aqueous solution. In comparison with calculated activation energies for other nucleotides the 3′-GMP has the lowest energy barrier in aqueous solution.

Zetasizer Nano Helps Establish Size Independence In DNA Driven Nanoparticle Structuring

Malvern, UK - A research team led by Dr Oleg Gang at the Brookhaven Center for Functional Nanomaterials (CFN) in New York is using the Zetasizer Nano particle characterization system from Malvern Instruments in ground-breaking work that has demonstrated successful DNA-guided formation of ordered 3-D crystalline structures. DNA's natural ability to self-assemble according to pre-programmed genetic codes within its pairing bases makes it the perfect architectural device for construction of novel crystalline structures. The ability to engineer such 3-D structures enables the production of functional materials that take advantage of the unique properties that may exist at the nanoscale - for example, enhanced magnetism, improved catalytic activity, or new optical properties

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