First sequence based map of large scale structural variation across the human genome: related news

First sequence-based map of large-scale structural variation across the human genome

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Researchers Produce First Sequence Map of Large-Scale Structural Variation in Human Genome

A nationwide team of researchers, funded in part by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), has produced the first sequence-based map of large-scale structural variation across the human genome. The work, published in the journal "Nature", provides a starting point to examine how such DNA variation contributes to human health and disease.

Researchers produce first sequence map of large-scale structural variation in human genome

A nationwide team of researchers, funded in part by the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), has produced the first sequence-based map of large-scale structural variation across the human genome. The work, published today in the journal Nature, provides a starting point to examine how such DNA variation contributes to human health and disease.

Researchers urge ethics guidelines for human-genome research

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Can IT fuel the race to the $1,000 human genome?

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8 new human genome projects offer large-scale picture of genetic difference

A nationwide consortium led by the University of Washington in Seattle has completed the first sequence-based map of structural variations in the human genome, giving scientists an overall picture of the large-scale differences in DNA between individuals. The project gives researchers a guide for further research into these structural differences, which are believed to play an important role in human health and disease. The results appear in the May 1 issue of the journal Nature.

Human genome projects offer large-scale picture of genetic difference

A nationwide consortium led by the University of Washington in Seattle has completed the first sequence-based map of structural variations in the human genome, giving scientists an overall picture of the large-scale differences in DNA between individuals.

Eight new Human Genome Projects Offer Large-Scale Picture of Genetic Differences among Individual

A nationwide consortium led by the University of Washington in Seattle has completed the first sequence-based map of structural variations in the human genome, giving scientists an overall picture of the large-scale differences in DNA between individuals.

New Map Reveals Dynamic Variation in Human Genome

A team of researchers led by Howard Hughes Medical Institute investigator Evan E. Eichler at the University of Washington has produced the first high-resolution map showing the structural variation that exists in the human genome. With the map, researchers can now begin to see how the underlying structure of one person's genome differs from that of another.

Applied Biosystems Surpasses Industry Milestone in Lowering the Cost of Sequencing Human Genome

17 Mar 2008 - Applied Biosystems, an Applera Corporation business, announced a significant development in the quest to lower the cost of DNA sequencing. Scientists from the company have sequenced a human genome using its next-generation genetic analysis platform. The sequence data generated by this project reveal numerous previously unknown and potentially medically significant genetic variations. It also provides a high-resolution, whole-genome view of the structural variants in a human genome, making it one of the most in-depth analyses of any human genome sequence. Applied Biosystems is making this information available to the worldwide scientific community through a public database hosted by the National Center for Biotechnology Information (NCBI).

Applied Biosystems Surpasses Industry Milestone in Lowering the Cost of Sequencing Human Genome

Applied Biosystems (NYSE:ABI), an Applera Corporation business, today announced a significant development in the quest to lower the cost of DNA sequencing. Scientists from the company have sequenced a human genome using its next-generation genetic analysis platform. The sequence data generated by this project reveal numerous previously unknown and potentially medically significant genetic variations. It also provides a high-resolution, whole-genome view of the structural variants in a human genome, making it one of the most in-depth analyses of any human genome sequence. Applied Biosystems is making this information available to the worldwide scientific community through a public database hosted by the National Center for Biotechnology Information (NCBI).

Applied Biosystems Surpasses Industry Milestone in Lowering the Cost of Sequencing Human Genome

FOSTER CITY, Calif.--(BUSINESS WIRE)--Applied Biosystems (NYSE:ABI - News), an Applera Corporation business, today announced a significant development in the quest to lower the cost of DNA sequencing. Scientists from the company have sequenced a human genome using its next-generation genetic analysis platform. The sequence data generated by this project reveal numerous previously unknown and potentially medically significant genetic variations. It also provides a high-resolution, whole-genome view of the structural variants in a human genome, making it one of the most in-depth analyses of any human genome sequence. Applied Biosystems is making this information available to the worldwide scientific community through a public database hosted by the National Center for Biotechnology Information (NCBI).

Applied Biosystems Surpasses Industry Milestone in Lowering the Cost of Sequencing Human Genome

FOSTER CITY, Calif.--(BUSINESS WIRE)--Mar 12, 2008 - Applied Biosystems (NYSE:ABI), an Applera Corporation business, today announced a significant development in the quest to lower the cost of DNA sequencing. Scientists from the company have sequenced a human genome using its next-generation genetic analysis platform. The sequence data generated by this project reveal numerous previously unknown and potentially medically significant genetic variations. It also provides a high-resolution, whole-genome view of the structural variants in a human genome, making it one of the most in-depth analyses of any human genome sequence. Applied Biosystems is making this information available to the worldwide scientific community through a public database hosted by the National Center for Biotechnology Information (NCBI).

Researchers Use 454 Sequencing to Publish the Complete Genome of an Individual Human, Achieving a Key Milestone on the Path to Personalized Genome Sequencing

BRANFORD, Conn.--(BUSINESS WIRE)--Apr 17, 2008 - 454 Life Sciences, a centre of excellence of Roche Applied Science, today announced that researchers at Baylor College of Medicine and 454 have published the complete DNA sequence and analysis of an individual human diploid genome. The genome was analyzed using the 454 Sequencing technology to 7.4 redundancy, facilitating a detailed comparison against the publicly available reference human sequence. The study, entitled "The complete genome of an individual by massively parallel DNA sequencing" appears today in the journal Nature.

First African Human Genome Sequenced

Illumina, Inc., San Diego, announced that company scientists sequenced the genome of an anonymous African male (Yoruba from Ibadan, Nigeria), using the Genome Analyzer. Sequencing of this HapMap sample was conducted internally and marks the first human genome sequence generated exclusively with paired reads of 35 to 50 bases in length. The project was completed in a matter of weeks, according to the company.

Superbug genome sequenced

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Beetle genome opens the door to developmental research

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New chemicals shield 'genome guardian'

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Scientists sequence pest beetle genome

An international research consortium has reported the genome sequence of the red flour beetle Tribolium castaneum, the first for an insect pest. Tribolium is a notorious invader of stored grains and grain products. The genome consists of approximately 200 million DNA bases that code for about 16,000 proteins, one third of which represents repetitive sequences. The study may have a big impact on agriculture as development in Tribolium is more representative of other insects than is Drosophila (the first insect with its genome sequence).

The $100 Genome

It currently costs roughly $60,000 to sequence a human genome, and a handful of research groups are hoping to achieve a $1,000 genome within the next three years. But two companies, Complete Genomics and BioNanomatrix, are collaborating to create a novel approach that would sequence your genome for less than the price of a nice pair of jeans--and the technology could read the complete genome in a single workday. "It would have been absolutely impossible to think about this project 10 years ago," says Radoje Drmanac, chief scientific officer at Complete Genomics, which is based in Mountain View, CA.

Platypus genome unravels mysteries of mammalian evolution

Genome Research is publishing several papers related to analyses of the duck-billed platypus (Ornithorhynchus anatinus) genome sequence. The place of (egg-laying) monotremes, such as the platypus, in mammalian evolutionary history has remained controversial. Now, researchers are finding that the distinctive anatomical and physiological properties of the platypus are reflected in the newly sequenced platypus genome. Through comparative genomics, the platypus genome is providing remarkable insights into the evolution of venom components, the sex-determination system, testicular descent, and small RNA pathways. Primary research reports describing these novel insights will appear online May 8, concurrent with publication of the platypus genome sequence report in the journal Nature.

Scientists Find A Fingerprint Of Evolution Across The Human Genome

The Human Genome Project revealed that only a small fraction of the 3 billion “letter” DNA code actually instructs cells to manufacture proteins, the workhorses of most life processes. This has raised the question of what the remaining part of the human genome does. How much of the rest performs other biological functions, and how much is merely residue of prior genetic events?

Scientists find a fingerprint of evolution across the human genome

The Human Genome Project revealed that only a small fraction of the 3 billion �letter� DNA code actually instructs cells to manufacture proteins, the workhorses of most life processes. This has raised the question of what the remaining part of the human genome does. How much of the rest performs other biological functions, and how much is merely residue of prior genetic events"

Scientists find a fingerprint of evolution across the human genome

The Human Genome Project revealed that only a small fraction of the 3 billion �letter� DNA code actually instructs cells to manufacture proteins, the workhorses of most life processes. This has raised the question of what the remaining part of the human genome does. How much of the rest performs other biological functions, and how much is merely residue of prior genetic events?

Scientists find a fingerprint of evolution across the human genome

The Human Genome Project revealed that only a small fraction of the 3 billion letter DNA code actually instructs cells to manufacture proteins, the workhorses of most life processes. This has raised the question of what the remaining part of the human genome does. How much of the rest performs other biological functions, and how much is merely residue of prior genetic events"

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