Viral DNA in bacterial genome could hold key to novel cystic fibrosis treatments: related news

Viral DNA in bacterial genome could hold key to novel cystic fibrosis treatments

December 2, 2008 The bacterium Pseudomonas aeruginosa is well known for its environmental versatility, ability to cause infection in humans, and its capacity to resist antibiotics. P. aeruginosa is the most common cause of persistent and fatal lung infections in cystic fibrosis patients. In a study published online today in Genome Research (www.genome.org), researchers have used genomic techniques to study a particularly virulent strain of P. aeruginosa, uncovering genetic clues to its success that will aid in the design of novel therapeutic strategies.

Viral DNA in bacterial genome could hold key to novel cystic fibrosis treatments

The bacterium Pseudomonas aeruginosa is well known for its environmental versatility, ability to cause infection in humans, and its capacity to resist antibiotics. P. aeruginosa is the most common cause of persistent and fatal lung infections in cystic fibrosis patients. In a study published in Genome Research, researchers have used genomic techniques to study a particularly virulent strain of P. aeruginosa, uncovering genetic clues to its success that will aid in the design of novel therapeutic strategies.

Viral DNA In Bacterial Genome Could Hold Key To Novel Cystic Fibrosis Treatments

The bacterium Pseudomonas aeruginosa is well known for its environmental versatility, ability to cause infection in humans, and its capacity to resist antibiotics. P. aeruginosa is the most common cause of persistent and fatal lung infections in cystic fibrosis patients. In a study published online in Genome Research, researchers have used genomic techniques to study a particularly virulent strain of P. aeruginosa, uncovering genetic clues to its success that will aid in the design of novel therapeutic strategies.

Viral DNA In Bacterial Genome Could Hold Key To Novel Cystic Fibrosis Treatments

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Exposing Obama's Genome

Cheap genome screening is becoming ever more widely available. For example, the price of a genome screening test offered by Silicon Valley startup 23andMe has dropped from $999 to $399, and it now reveals even more genetic information to customers. Let's say the price for such tests falls to the price of over-the-counter paternity tests, making it inexpensive and easy for DNA collected from anyone to be screened. Collecting DNA from suspects is a standard plot device in television shows like CSI: Miami and is a facet of real life crime solving. Investigators pick up a cigarette butt, a soft drink can, a toothpick, or a hair follicle, and have the residual DNA sequenced. All of us shed DNA and anyone could pick up our DNA and send it in for screening.

Clean Genome E. coli MDS competent cells

Using synthetic biology methods, Scarab Genomics made a series of planned, precise deletions to the E. coli K-12 genome, reducing the genome by about 15 percent. The multiple-deletion series (MDS) strains eliminate non-essential genes, cryptic virulence genes, and sequences for recombinogenic and mobile insertion sequence DNA, while preserving robust growth in rich and minimal media. Genome reduction results in superior genomic and plasmid stability, high transformation efficiency, increased cloning success with “unclonable” genes, and improved E. coli metabolic efficiency. Clean Genome E. coli MDS strains are safer and offer reduced background to significantly improve many molecular biology applications. Clean Genome E. coli MDS Competent Cell efficiency: Electrocompetent Cells >1010 cfu/µg pUC 19; Chemically Competent Cells ≥108 cf

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology

Advance Allows for More Efficient Construction of Synthetic Genomes ROCKVILLE, Md., Dec. 4 /PRNewswire-USNewswire/ -- Researchers at the J. Craig Venter Institute (JCVI), a not-for-profit genomic research organization, have published a paper describing a significant advance in genome assembly in which the team can now assemble the whole bacterial genome, Mycoplasma genitalium, in one step from 25 fragments of DNA. Lead author Daniel G. Gibson, Ph.D. and his team published their results in the online early edition of the journal Proceedings of the National Academy of Sciences (PNAS). The work was funded by the company Synthetic Genomics Inc. (SGI). Today's publication represents major improvements in the methods that the team developed and described in their January 2008 publication of the first synthesis of a bacterial genome, M.

Nano "Tractor Beam" Traps DNA: Researchers use beams of light to grab and hold molecules

DNA molecules in a nanoscale channel get trapped by light. When DNA molecules suspended in a tiny stream of water flow through a nanoscale channel, they can be captured by a field of light if that light is confined in a device called a slot waveguide. The pressure from the light can then propel the DNA along the waveguide channel to bring the molecules to new locations. Such manipulation could prove valuable for assembling nanoscale structures, driving powerful sensors and developing a range of other technologies. Credit: Nicolle Rager Fuller, National Science Foundation

Understanding Public Key Infrastructure

Last week we took a look at how public key encryption systems work, and how anyone can send you an encrypted message—which only you can read—if they have access to your public key. It turns out that the process of getting your public key to people who need to use it is a complex task that involves a combination of trust, third parties, and various other factors which together are known as public key infrastructure.

Doing quality control on computerized genome science

Anybody that has followed our remarkable progress with genome sequencing is aware that the completion of each genome brings a number—usually in the low tens-of-thousands—of genes found in the DNA of the species involved. Some of these numbers gave human pride a body-blow, as we wouldn't have expected to have only a few thousand more genes than the worm, and half as many as a rice plant. But we've never actually confirmed that the majority of these genes exist, and most were predicted by computer programs that scan the DNA sequence, searching for signs of a gene. Two recent papers have performed a quality check on these programs, and found that they do make an appreciable number of errors—just nowhere near enough to give us more genes than rice.

#9: Your Genome, Now Available for a (Relative) Discount

A new chapter of faster, cheaper personal genomics began in 2008, accompanied by a flurry of regulatory concerns and ethical alerts. In April researchers reported sequencing the entire genome of DNA pioneer James Watson, a project that took only two months and cost less than $1 million. It was just the second individual human genome ever fully sequenced. The first, in 2007, took about a year and cost roughly 60 times as much. Chris McLeod, president and CEO of 454 Life Sciences, which was involved in the Watson project, says his company’s newest sequencing instrument can now do one human genome in about a month for roughly $200,000.

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology; Yeast as a Genetic Factory

Researchers at the J. Craig Venter Institute (JCVI) have published a paper describing a significant advance in genome assembly in which the team can now assemble the whole bacterial genome, Mycoplasma genitalium, in one step from 25 fragments of DNA. Lead author Dr. Daniel G. Gibson and his team published their results in the online early edition of the journal Proceedings of the National Academy of Sciences (PNAS). The work was funded by the company Synthetic Genomics Inc. (SGI).

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology

Researchers at the J. Craig Venter Institute (JCVI), a not-for-profit genomic research organization, have published a paper describing a significant advance in genome assembly in which the team can now assemble the whole bacterial genome, Mycoplasma genitalium, in one step from 25 fragments of DNA.

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology

ROCKVILLE, Md., December 04, 2008 /PRNewswire-USNewswire/ -- Researchers at the J. Craig Venter Institute (JCVI), a not-for-profit genomic research organization, have published a paper describing a significant advance in genome assembly in which the team can now assemble the whole bacterial genome, in one step from 25 fragments of DNA. Lead author Daniel G. Gibson, Ph.D. and his team published their results in the online early edition of the journal (PNAS). The work was funded by the company Synthetic Genomics Inc. (SGI).

Genome study focuses search for cancer treatments

The quest for personalised cancer treatments has been given a boost by the announcement of a GBP8.5m ($13m) UK-US alliance to find the best treatments for cancers.

Evolutionary Roots Of Ancient Bacteria May Open New Line Of Attack On Cystic Fibrosis

The redox-active pigments responsible for the blue-green stain of the mucus that clogs the lungs of children and adults with cystic fibrosis (CF) are primarily signaling molecules that allow large clusters of the opportunistic infection agent, Pseudomonas aeruginosa, to organize themselves into structured communities, report Massachusetts Institute of Technology geobiologists at American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco.*

DNA database 'violates human rights'

THE UK has led the world in forensic DNA profiling for law enforcement - but now the European Court of Human Rights (ECHR) has ruled that the UK's national DNA database has gone too far. In a landmark judgement on 4 December, the court ruled that the UK's Home Office must remove over 800,000 of about 4.5 million profiles in the database, and destroy the DNA samples.

FL's DNA Database Most Successful in Country

Florida’s DNA database has linked more felons’ DNA samples to crime-scene evidence than any other state DNA database in the country, according to the FBI. Orlando’s regional lab is the busiest of the states eight labs, making 453 hits in the past fiscal year.

Breast Cancer Genome Shows Evolution, Instability Of Cancer

A newly published genome sequence of a breast cancer cell line reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report in the journal Genome Research.

Breast cancer genome shows evolution, instability of cancer

A newly published genome sequence of a breast cancer cell line reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report that appears online in the journal Genome Research.

Breast Cancer Genome Shows Evolution

A newly published genome sequence of a breast cancer cell line reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report that appears online in the journal Genome Research.

Neanderthal Genome Yields to Study

At a human evolution conference last week it was announced that half the Neanderthal genome has been decoded. But due to the fragmentary state of the DNA sample, which was taken from bones, the first draft will offer only a glimpse of the genome to researchers who hope to better understand Neanderthal biology and human evolution.

Gold rolls DNA nanotubes

Gold nanoparticles attached by single DNA strands to two-dimensional DNA bundles or sheets cause the DNA to curl up into nanotubes. The size of the nanoparticles determines the size and shape the nanotubes.

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