Protein regulating drug response to Kala azar identified: related news

Protein regulating drug response to Kala-azar identified

Mumbai (PTI): Scientists from the National Institute of Immunology (NII) have identified a crucial protein that has an important role in regulating the infectivity, survival and drug response of the parasite that causes visceral leishmaniasis or the dreaded `Kala-azar'.

A General and Rapid Cell-Free Approach for the Interrogation of Protein'Protein, Protein'DNA, and Protein'RNA Interactions and their Antagonists Utilizing Split-Protein Reporters

A General and Rapid Cell-Free Approach for the Interrogation of Protein−Protein, Protein−DNA, and Protein−RNA Interactions and their Antagonists Utilizing Split-Protein Reporters

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Deconstructing Green Fluorescent Protein

Green fluorescent protein (GFP) has been reassembled from two pieces, a large fragment 214 amino acids in length that is produced recombinantly (GFP 1−10) and a short synthetic peptide corresponding to the 11th stave of the β-barrel that is 16 amino acids long (synthetic GFP 11), following a system developed by Waldo and co-workers (Cabantous, S.; et al. Nat. Biotechnol. 2005, 23, 102−7) as an in vivo probe for protein association and folding. We demonstrate that the reassembled protein has identical absorption and excited-state proton transfer dynamics as a whole protein of the identical sequence. We show that the reassembled protein can be taken apart and the peptide replaced with a different synthetic peptide designed to perturb the chromophore absorption.

New Role Of Inflammatory Protein In Polycycstic Kidney Disease Identified, Could Lead To Treatment

The Stowers Institute’s Rong Li Lab has discovered that a protein previously shown to have a role in inflammation may also have a role in the formation of cysts in Autosomal Dominant Polycystic Kidney Disease (ADPKD) — one of the most common life-threatening genetic diseases — and has shown that a drug inhibiting the protein can slow the disease in mice.

Redefining Drug Delivery

One of the biggest problems with ­conventional drug delivery is that it is often ineffective at shuttling medicine to where it is needed in the body. For instance, the digestive system and the liver often thoroughly degrade orally delivered drugs before they can reach the bloodstream, making a variety of drugs such as those composed of proteins and peptides unsuitable for oral administration. Though injecting drugs into the body avoids the problem of first-pass metabolism, many drugs quickly decay after injection and the rate of drug absorption is typically difficult to control in that delivery route. Other drug-delivery methods face similar problems. “If you consider some of the common methods for delivery of protein and peptide drugs, you end up with a bioavailability that is often very low,” says John Santini, president and CEO of

CEM's Sprint™ Rapid Protein Analyzer Provides Protein Determination in Two Minutes

CEM’s Sprint™ Rapid Protein Analyzer provides a protein determination in 2 minutes that is claimed to be more accurate than Kjeldahl and does not use harsh chemicals or high heat.

NanoViricides Inc. Posts Photos Showing Rapid Response of Animals to Treatment with EKC Eye Drug Candidate

NanoViricides Inc. Posts Photos Showing Rapid Response of Animals to Treatment with EKC Eye Drug Candidate

Effect of Cocaine on Fas-Associated Protein with Death Domain in the Rat Brain: Individual Differences in a Model of Differential Vulnerability to Drug Abuse

Effect of Cocaine on Fas-Associated Protein with Death Domain in the Rat Brain: Individual Differences in a Model of Differential Vulnerability to Drug Abuse

BioExx Files Process Patent Application for Production of Unique Protein Concentrates and Protein Isolates

BioExx Files Process Patent Application for Production of Unique Protein Concentrates and Protein Isolates

BioExx Files Process Patent Application for Production of Unique Protein Concentrates and Protein Isolates

BioExx Files Process Patent Application for Production of Unique Protein Concentrates and Protein Isolates

Protein predicts Gleevec resistance in gastrointestinal tumors

Excess amounts of a protein called IGF-1R in patients with gastrointestinal stromal tumors (GISTs) could indicate that the patient would be less responsive to the drug imatinib mesylate (known as Gleevec), according to Andrew K. Godwin, Ph.D., a researcher at the Fox Chase Cancer Center in Philadelphia. Preliminary studies have shown that GIST cells, especially Gleevec-resistant cells, might respond well to agents in development for treatment-resistant breast cancer, a form of breast cancer also marked by excessive production of the IGF-1R protein. IGF-1R could also serve as a marker to identify this subset of GIST patients before therapy begins, when alternative treatments would be most effective, the researcher says.

Novel Protein Nanoparticles 'Shape' the Future of Disease

Researchers at the University of North Carolina-Chapel Hill (UNC) have granted an exclusive license to Liquidia Technologies for a protein particle fabrication method that could greatly expand the reach of protein therapeutics. Proteins are large organic molecules that perform highly specific and complex functions in the body, making them an ideal instrument to diagnose and cure disease. However, protein solubility, distribution, stability, and aggregation have hampered the development of this therapeutic class.

Potential Protein Biomarkers For Growth Hormone Identified

Ohio University scientists have identified several proteins in mice that might act as biomarkers for growth hormone. The research could be the first step to finding a more reliable way to detect recombinant human growth hormone (rhGH), which some athletes and teenagers use illegally in an effort to boost muscle and reduce fat.

Primetime for Protein Arrays

Protein microarrays allow researchers to analyze expression, protein interactions, and more. Recent advances eliminate those pesky purification steps, making these arrays more reliable and stable.

Protein that defends against HIV found

NEW YORK: Scientists have identified a protein that restricts the release of HIV-1 virus from human cells — a major breakthrough in AIDS research which they claim could lead to finding new treatments.

Protein Found To Promote Antibiotic Resistance In A Common Food-borne Pathogen

Researchers from Iowa State University have identified a novel factor that promotes the development of antibiotic resistance in a bacterial pathogen. The study explains that Mfd, a protein involved in DNA transcription and repair, plays an important role in the development of fluoroquinolone resistance in Campylobacter, a bacterial pathogen commonly associated with food poisoning in humans.

Lasers Used To Align Molecules: Technique Could Revolutionize Human Protein Imaging

Protein crystallographers have only scratched the surface of the human proteins important for drug interactions because of difficulties crystallizing the molecules for synchrotron x-ray diffraction.

Protein found to promote antibiotic resistance in a common food-borne pathogen

Researchers from Iowa State University have identified a novel factor that promotes the development of antibiotic resistance in a bacterial pathogen. The study, published June 6th in the open-access journal PLoS Pathogens, explains that Mfd, a protein involved in DNA transcription and repair, plays an important role in the development of fluoroquinolone resistance in Campylobacter, a bacterial pathogen commonly associated with food poisoning in humans.

New protein discovered in dental cancers

U.S. scientists say they've identified a structurally unique protein in dental and other epithelial cancers.

New protein discovered in dental cancers

U.S. scientists say they've identified a structurally unique protein in dental and other epithelial cancers.

Enhanced Protein Tomography™ Method for Rapid Epitope Determination

Sidec has introduced a new version of its Protein Tomography™ technology. The new developments improve the analysis of therapeutic antibodies and drug targets in biological systems, the company says.

DDT resistance protein found in mosquitoes

U.S. scientists said they have identified a key detoxifying protein in Anopheles mosquitoes that metabolizes DDT.

Heart healthy protein found using frogs

HONG KONG (Reuters) - Scientists in Japan have identified a protein that appears to help develop a healthy heart, according to initial studies done on frogs.

Overcoming Drug Resistance-Nanoparticles Trigger Built-In Cell-Death Signal

One of the most vexing problems in treating cancer is the propensity of tumors to develop resistance to a wide range of anticancer drugs. Over 70 percent of ovarian cancer patients, for example, have drug-resistant tumors at the time of their initial diagnosis, and virtually all patients who relapse have drug-resistant tumors.

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