Protein Attributed to Membrane Repair Identified Mechanism May Revolutionize Therapy in Human Disease: related news

Protein Attributed to Membrane Repair Identified - Mechanism May Revolutionize Therapy in Human Disease

Researchers at UMDNJ-Robert Wood Johnson Medical School have identified the protein MG53, as a key initiator of membrane repair in damaged tissue. The study, released today in Nature Cell Biology, is the first to specifically pinpoint a protein responsible for promoting cell repair.

Absence of CLP protein can be indicative of oral cancer

Poulsbo, WA – January 7, 2009 – Human calmodulin-like protein (CLP) is found in many cell types including breast, thyroid, prostate, kidney, and skin. The protein can regulate many cell activities and has a highly specific expression. Gaining an understanding about the expression of CLP in oral epithelial cells and its possible downregulation (or lack of production) in cancer may be a potentially valuable marker in early detection of oral cancer. A new study in the Journal of Prosthodontics found that CLP is expressed in normal human oral muscosal cells and that downregulation of this protein may be an indicator of malignancy or cancer.

ExonHit Launches Mouse Genome SpliceArray for use in Human Disease Modeling Studies

PARIS, November 28, 2008 /PRNewswire-FirstCall/ -- ExonHit Therapeutics S.A. (Alternext: ALEHT), a drug and diagnostic discovery company, announces today the availability of its new SpliceArray(TM) for use in studying mouse models of human disease. These SpliceArray(TM) products help our clients accelerate and refine their therapeutic target discovery and validation efforts. Using our high resolution expression profiling analysis, we identify novel transcripts coding for new protein variants that may be involved in various genetic disorders such as oncology, central nervous system, or immune system disorders. This mouse SpliceArray(TM) products represent the achievement of more two years of work by our R&D team after the launch of the Human genome SpliceArray(TM) in 2007 and the rat genome SpliceArray(TM) earlier this year.

New Mouse Model Of Prion Disease: Mutant Proteins Result In Infectious Prion Disease In Mice

A worldwide group of scientists has created an infectious prion disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals. The research team, including Christina J. Sigurdson, D.V.M., Ph.D., assistant professor of pathology at the University of California, San Diego School of Medicine, also discovered that changing the structure of the prion protein by altering just two nucleic acids leads to a fatal neurological disorder in mice.

Antitumor Gene that Smothers Protein Abundant in Many Forms of Cancer Identified

Researchers have identified a new anti-tumor gene called SARI that can interact with and suppress a key protein that is overexpressed in 90% of human cancers.

Alzheimer?s disease cure may come from cold sore virus

British researchers have discovered that the virus causing cold sores (herpes simplex virus type 1) is also the primary reason why amyloid plaques are found in the brains of Alzheimer’s disease patients. The research may one day lead to a way to effectively treat AD patients and prevent the disease from ever taking away memories.

Alzheimer's disease cure may come from cold sore virus

British researchers have discovered that the virus causing cold sores (herpes simplex virus type 1) is also the primary reason why amyloid plaques are found in the brains of Alzheimer’s disease patients. The research may one day lead to a way to effectively treat AD patients and prevent the disease from ever taking away memories.

Canadian Museum for Human Rights launches virtual exhibition

The Canadian Museum for Human Rights may not be set to open until 2012, but it launched its first virtual exhibition yesterday. To mark the 60th anniversary of the signing of the Universal Declaration of Human Rights on Dec. 10, 1948, the museum premiered an exhibit at the University of Winnipeg that explores the life of John Peters Humphrey, right, the Canadian legal scholar and principal author of the Declaration. The document arose from the experience of the Second World War and represents the first global expression of rights to which all human beings are inherently entitled. The exhibit, which used digitized artifacts from Library Archives Canada and McGill University Archives, can be viewed online at www.humanrightsmuseum.

Mutant proteins have created infectious prion disease in mice

A worldwide group of scientists has created an infectious prion disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals. The research team, including Christina J. Sigurdson, D.V.M., Ph.D., assistant professor of pathology at the University of California, San Diego School of Medicine, also discovered that changing the structure of the prion protein by altering just two nucleic acids leads to a fatal neurological disorder in mice. Their findings will be published on line in Proceedings of the National Academy of Sciences (PNAS) the week of December 1.

Mutant proteins result in infectious prion disease in mice

A worldwide group of scientists has created an infectious prion disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals. The research team, including Christina J. Sigurdson, D.V.M., Ph.D., assistant professor of pathology at the University of California, San Diego School of Medicine, also discovered that changing the structure of the prion protein by altering just two nucleic acids leads to a fatal neurological disorder in mice. Their findings will be published on line in Proceedings of the National Academy of Sciences (PNAS) the week of December 1.

Mutant proteins result in infectious prion disease in mice

A worldwide group of scientists has created an infectious prion disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals. The research team, including Christina J. Sigurdson, D.V.M., Ph.D., assistant professor of pathology at the University of California, San Diego School of Medicine, also discovered that changing the structure of the prion protein by altering just two nucleic acids leads to a fatal neurological disorder in mice. Their findings will be published on line in Proceedings of the National Academy of Sciences (PNAS) the week of December 1.

Hubble Repair Mission Will Launch in May '09

NASA announced Thursday that space shuttle Atlantis' STS-125 mission to repair the Hubble Space Telescope is targeted to launch May 12, 2009. The mission, which was previously scheduled for October of this year was delayed when a data handling unit on the telescope failed. Since then, engineers have been working to prepare a 1970's era spare unit for flight. They expect to be able to ship the spare, known as the Science Instrument Command and Data Handling System, to NASA's Kennedy Space Center in Florida in spring 2009.

Unravelling gene-protein matrix to pinpoint disease, remedies

Stephen Michnick is helping unravel the gene-protein matrix to pinpoint disease and remedies, besides figuring out the basic architecture of life.

Cell phones may cause heart disease, kidney failure

People should stay miles away from mobile phones if they're mindful of their health, for a new study has found that the handsets may lead to heart disease and kidney stones.

Single letter in human genome linked with elevated cholesterol levels identified

A group of researchers claims to have identified a single letter in the human genome that points to the risk for high cholesterol.

Single letter in human genome linked with elevated cholesterol levels identified

A group of researchers claims to have identified a single letter in the human genome that points to the risk for high cholesterol.

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