Of Mice and Methylation: related news

Of Mice and Methylation

Eric Lander's group has a new paper in the advance online section of Nature in which they describe how they used high-throughput reduced representation bisulphite sequencing coupled with single-molecule-based sequencing to generate DNA methylation maps from mouse primary tissues, including embryonic stem cells, embryonic-stem-cell-derived, and primary neural cells. They found that methylation patterns correlate with histone methylation patterns rather than with the genome sequence. They also say that CpG methylation is dynamic and that weak CpG islands associated with certain development genes undergo hypermethylation in vitro in a pattern they say is similar to what occurs in tumors.

Resveratrol found to improve health, but not longevity in aging mice on standard diet

Scientists have found that the compound resveratrol slows age-related deterioration and functional decline of mice on a standard diet, but does not increase longevity when started at middle age. This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, is a follow-up to 2006 findings that resveratrol improves health and longevity of overweight, aged mice. The report confirms previous results suggesting the compound, found naturally in foods like grapes and nuts, may mimic, in mice, some of the effects of dietary or calorie restriction, the most effective and reproducible way found to date to alleviate age-associated disease in mammals.

Resveratrol found to improve health, but not longevity in aging mice on standard diet

Scientists have found that the compound resveratrol slows age-related deterioration and functional decline of mice on a standard diet, but does not increase longevity when started at middle age. This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, is a follow-up to 2006 findings that resveratrol improves health and longevity of overweight, aged mice. The report confirms previous results suggesting the compound, found naturally in foods like grapes and nuts, may mimic, in mice, some of the effects of dietary or calorie restriction, the most effective and reproducible way found to date to alleviate age-associated disease in mammals.

Cancer Resistance Technique Moves To Human Trials

TaeKwonDood tips us to news that a new cancer resistance treatment is going into clinical trials after being quite successful at eradicating cancer in mice. Researchers discovered that certain white blood cells called granulocytes from cancer-immune mice were able to cure cancer in other mice. Now, doctors are putting out the call for healthy granulocyte donors in order to test how well it works on humans. The article quotes lead researcher Zheng Cui saying, "In mice, we've been able to eradicate even highly aggressive forms of malignancy with extremely large tumors. Hopefully, we will see the same results in humans. Our laboratory studies indicate that this cancer-fighting ability is even stronger in healthy humans."

Towards an Exercise Pill

aztektum among many other readers sent us news that medical researchers have developed two drugs that can build muscle tone in mice without exercise. While such an advance may inspire dreams of a "couch potato pill," the article mostly talks about other medical uses, should the drugs prove safe and effective in humans. The doctor in charge of the research is working with sports authorities to develop a test to detect the drugs in athletes. "Researchers at the Salk Institute in San Diego reported that they had found two drugs that did wonders for the athletic endurance of couch potato mice. One drug, known as Aicar, increased the mice's endurance on a treadmill by 44 percent after just four weeks of treatment. A second drug, GW1516, supercharged the mice to a 75 percent increase in endurance but had to be combined with exercise to have any

Mice livers stopped from ageing: study

Researches are now able to stop ageing in mice by halting harmful build-up of proteins in the liver.Researches are now able to stop ageing in mice by halting harmful build-up of proteins in the liver.

Starvation Hormone Makes For Small Mice, Study Finds

Chronically high levels of a recently discovered starvation hormone markedly stunt the growth of mice, reveals a new study in the July issue of Cell Metabolism, a publication of Cell Press. The liver-produced hormone known as FGF21 does so by causing the mice to become resistant to growth hormone.

Vaccine Containing Tumor Antigen Reduces Colon Cancer Spread in Mice Axentis Pharma Gains Patents from BioDevelops Pharma to Further Cystic Fibrosis Program Articles Most Viewed Most Emailed Top Searches Optimizing Utilization of Biomarkers Meth

Scientists at the Kimmel Cancer Center at Jefferson Medical College have found a way to immunize mice against the development of metastatic disease. Their approach is based on the fact that the intestines have a separate immune system from the rest of the body. The researchers were able to show that mice immunized with an intestinal protein developed fewer lung and liver metastases after injection with colon cancer cells than did control animals.

Study: hungry mice are happy mice

BEIJING, July 15 (Xinhuanet) -- Unhappy and want to be happy? A new study says you should get hungry.

Study: hungry mice are happy mice

When our bodies notice we need more calories, levels of a hormone called ghrelin increase. Ghrelin is known to trigger hunger, but new research suggests this may be a side effect of its primary job as a stress-buster.

Cancer cure in mice to get human trials: Wake Forest University scientists studying genetic immunity in mice to start testing humans

Jun. 29--Clinical trials begin this week at Wake Forest University on a cancer therapy that has completely cured the disease in every mouse tested over the past few years.

MICE Among the Vines - Parehua Country Estate

Meetings, conferences and incentive rewards, all MICE requirements among the vines at Parehua Martinborough Country Estate’s luxurious accommodation (up to 30 singles or option of twin share) and new The Terrace Room (up to 60 pax) and The Boardroom (15 pax).

Pregnant mice block out unwelcome admirers

Such mice block the smell of their urine that can cause miscarriage, besides reactivating the ovulatory cycle.

Pregnant mice block out unwelcome admirers

Such mice block the smell of their urine that can cause miscarriage, besides reactivating the ovulatory cycle.

Bedbugs, mice found in British hospitals

British Conservatives said the Labor party isn't doing enough to keep pests such mice, rats and bedbugs out of National Health Service hospitals.

Boozing mice get the blues when they dry out

Clyde Hodge of the University of Carolina at Chapel Hill and his colleagues found that mice who voluntarily drank moderate amounts of alcohol exhibited depression-like behaviour when the alcohol was withdrawn.

Bedbugs, mice found in British hospitals

LONDON, Aug. 7 (UPI) -- British Conservatives said the Labor party isn't doing enough to keep pests such mice, rats and bedbugs out of National Health Service hospitals.

Boozing mice ?€?get the blues?€™ on abstinence

London, July 24 : It’s not just humans who get the blues when they abstain from alcohol, for even mice become depressed and lose brain cells when they stay away from liquor, says a new study.

FAA: Mice caused small plane to crash

NORTH STONINGTON, Conn., Aug. 13 (UPI) -- A pilot whose single-engine Cessna crashed in North Stonington, Conn., said investigators told him the crash was caused by mice aboard the plane.

Pregnant Mice Block Odor Of Strange Male's Urine To Protect Their Pups

Mouse mothers-to-be have a remarkable way to protect their unborn pups. Because the smell of a strange male's urine can cause miscarriage and reactivate the ovulatory cycle, pregnant mice prevent the action of such olfactory stimuli by blocking their smell. Researchers from the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, have now revealed the nature of this ability. A surge of the chemical signal dopamine in the main olfactory bulb - one of the key brain areas for olfactory perception -- creates a barrier for male odours, they report in the current issue of Nature Neuroscience.

Pregnant mice block out unwelcome admirers to protect their pups

Mouse mothers-to-be have a remarkable way to protect their unborn pups. Because the smell of a strange male's urine can cause miscarriage and reactivate the ovulatory cycle, pregnant mice prevent the action of such olfactory stimuli by blocking their smell. Researchers from the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, have now revealed the nature of this ability. A surge of the chemical signal dopamine in the main olfactory bulb - one of the key brain areas for olfactory perception – creates a barrier for male odours, they report in the current issue of Nature Neuroscience.

Pregnant mice block out unwelcome admirers to protect their pups

Mouse mothers-to-be have a remarkable way to protect their unborn pups. Because the smell of a strange male's urine can cause miscarriage and reactivate the ovulatory cycle, pregnant mice prevent the action of such olfactory stimuli by blocking their smell. Researchers from the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, have now revealed the nature of this ability. A surge of the chemical signal dopamine in the main olfactory bulb - one of the key brain areas for olfactory perception – creates a barrier for male odours, they report in the current issue of Nature Neuroscience.

Latest: Boozing mice get the blues when they dry out

Clyde Hodge of the University of Carolina at Chapel Hill and his colleagues found that mice who voluntarily drank moderate amounts of alcohol exhibited depression-like behaviour when the alcohol was withdrawn.

Study of dark-skinned mice leads to protein linked to bone marrow failure in humans

The study of dark-skinned mice has led to a surprising finding about a common protein involved in tumor suppression, report researchers at the Stanford University School of Medicine. The results may lead to new treatments for bone marrow failure in humans.

Natural Cartilage Repair In Mice Studied

U.S. scientists say they're studying mice that can naturally regenerate cartilage to find ways to improve treatment of damaged human cartilage.

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