Human genome projects offer large scale picture of genetic difference: related news

First sequence-based map of large-scale structural variation across the human genome

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8 new human genome projects offer large-scale picture of genetic difference

A nationwide consortium led by the University of Washington in Seattle has completed the first sequence-based map of structural variations in the human genome, giving scientists an overall picture of the large-scale differences in DNA between individuals. The project gives researchers a guide for further research into these structural differences, which are believed to play an important role in human health and disease. The results appear in the May 1 issue of the journal Nature.

Human genome projects offer large-scale picture of genetic difference

A nationwide consortium led by the University of Washington in Seattle has completed the first sequence-based map of structural variations in the human genome, giving scientists an overall picture of the large-scale differences in DNA between individuals.

Eight new Human Genome Projects Offer Large-Scale Picture of Genetic Differences among Individual

A nationwide consortium led by the University of Washington in Seattle has completed the first sequence-based map of structural variations in the human genome, giving scientists an overall picture of the large-scale differences in DNA between individuals.

Researchers Produce First Sequence Map of Large-Scale Structural Variation in Human Genome

A nationwide team of researchers, funded in part by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), has produced the first sequence-based map of large-scale structural variation across the human genome. The work, published in the journal "Nature", provides a starting point to examine how such DNA variation contributes to human health and disease.

Researchers produce first sequence map of large-scale structural variation in human genome

A nationwide team of researchers, funded in part by the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), has produced the first sequence-based map of large-scale structural variation across the human genome. The work, published today in the journal Nature, provides a starting point to examine how such DNA variation contributes to human health and disease.

Genetic link between Crohn's and asthma discovered

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Human vision inadequate for research on bird vision

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Superbug genome sequenced

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New chemicals shield 'genome guardian'

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A Genome in Any Format

In a recent post, Andrew Yates asked, "How much data is a human genome?" He then did a little math to show that an uncompressed diploid human genome would easily fit on two music CDs, if stored as a text file. That got Genetic Future's Daniel MacArthur thinking. There are, he says, other formats that a human genome could be stored in, including as images from an Illumina machine. In that format, a genome with 30x coverage would take up about 28.80 terabytes. Also, if the sequence data is stored as a Sequence Read Format file, the storage space'll top out at 1.98 terabytes.

First Draft of Oil Palm Genome Completed by Synthetic Genomics Inc and Asiatic Centre for Genome Technology

KUALA LUMPUR, Malaysia and LA JOLLA, Calif., May 21 /PRNewswire/ -- Asiatic Centre for Genome Technology Sdn Bhd (ACGT), which is focused on the commercial application of genome technology to improve oil palm and other crops and Synthetic Genomics Inc. (SGI), a privately held company dedicated to commercializing genomic-driven solutions to address global energy and environmental challenges, today announced the completion of a first draft assembly and annotation of the oil palm genome. The organizations also announced that they have made progress in sequencing and analyzing the jatropha genome. The oil palm and jatropha genome projects represent the first stages of research undertaken through a joint venture between SGI and ACGT which was announced in 2007 and is aimed at developing more high-yielding and disease-resistant plant feedstocks

US Department Of Energy Joint Genome Institute Announces New Genome Sequencing Projects

Walnut Creek, CA - In the continuing effort to tap the vast, unexplored reaches of the earth's microbial and plant domains for bioenergy and environmental applications, the DOE Joint Genome Institute (DOE JGI) has announced its latest portfolio of DNA sequencing projects that it will undertake in the coming year. The 44 projects, culled from nearly 150 proposals received through the Community Sequencing Program (CSP), represent over 60 billion nucleotides of data to be generated through this biodiversity sampling campaign—roughly the equivalent of 20 human genomes.

The FAQs about the human genome

COLD SPRING HARBOR, N.Y. – How many genes are in the human genome" Which genes are commonly associated with genetic diseases" How many mobile elements, simple sequence repeats, or protein kinases are encoded by the genome" What are the largest genes and proteins" How similar are human proteins to those of mouse, yeast, or bacteria"

The FAQs about the human genome

COLD SPRING HARBOR, N.Y. How many genes are in the human genome" Which genes are commonly associated with genetic diseases" How many mobile elements, simple sequence repeats, or protein kinases are encoded by the genome" What are the largest genes and proteins" How similar are human proteins to those of mouse, yeast, or bacteria"

Ancestry Surprises From New Genetics Analysis Method

An anonymous reader commends a recently published study involving a new way to analyze genetic variation in human populations (full article published in PLOS Genetics): "[S]cientists from Ireland, the UK and the US analysed 2,540 genetic markers in the DNA of almost 1,000 people from around the world whose genetic material had been collected by the Human Genome Diversity Project. The results include a number of surprises... the Yakut people of northern Siberia were found to have received a significant genetic contribution from the population of the Orkney Islands, which lie off the coast of Scotland... there must have been a period of gene flow from northern Europe to east Asia. The study also shed light on the peopling of the Americas, as the results suggest that the native populations of north and south America have different origins.

Platypus genome unravels mysteries of mammalian evolution

Genome Research is publishing several papers related to analyses of the duck-billed platypus (Ornithorhynchus anatinus) genome sequence. The place of (egg-laying) monotremes, such as the platypus, in mammalian evolutionary history has remained controversial. Now, researchers are finding that the distinctive anatomical and physiological properties of the platypus are reflected in the newly sequenced platypus genome. Through comparative genomics, the platypus genome is providing remarkable insights into the evolution of venom components, the sex-determination system, testicular descent, and small RNA pathways. Primary research reports describing these novel insights will appear online May 8, concurrent with publication of the platypus genome sequence report in the journal Nature.

Me and my genome

BACK in 2002, before the $3 billion Human Genome Project was even complete, some biologists began to talk of sequencing the entire genome of any individual for just $1000. While DNA sequencing is getting ever cheaper and faster, we are not quite there yet: about a tenth of the human genome remains impossible to sequence with existing methods.

Electronic Arts further extends tender offer for Take-Two

(RTTNews) - Video game maker Electronic Arts Inc. (ERTS) said Monday morning that it has extended its tender offer to acquire all the outstanding common shares of rival Take-Two Interactive Software, Inc. (TTWO) until June 16, 2008. The extension of the tender offer by the company for the third time comes even as shares of Take-Two trade higher than the offer price and the number of Take-Two shares tendered to the offer has declined. In response to Electronic Arts' announcement, Take-Two said that the recommendation of its board of directors to stockholders not to tender their shares to the offer remains unchanged. Take-Two, the publisher of the "Grand Theft Auto" series, has been resisting the hostile $2 billion buyout.

Scaling Large Projects With Erlang

Delchanat points out a blog entry which notes, "The two biggest computing-providers of today, Amazon as well as Google, are building their concurrent offerings on top of really concurrent programming languages and systems. Not only because they want to, but because they need to. If you want to build computing into a utility, you need large real-time systems running as efficiently as possible. You need your technology to be able to scale in a similar way as other, comparable utilities or large real-time systems are scaling — utilities like telephony and electricity. Erlang is a language that has all the right properties and mechanisms in place to do what utility computing requires. Amazon SimpleDB is built upon Erlang. IMDB (owned by Amazon) is switching from Perl to Erlang.

Genome Sequencer FLX System plus NimbleGen Sequence Capture Arrays Help Unravel the Cryptic Genetic Changes in Hematological Malignancies

PENZBERG, Germany--(BUSINESS WIRE)--Jul 8, 2008 - The Cancer Genomics Group at Barts and The London Medical School is researching leukemia with the aquisition of the state-of-the-art Genome Sequencer FLX System paired with the Roche NimbleGen Sequence Capture arrays. Researchers, led by Professor Brian Young, will use the combined technology of 454 Sequencing and NimbleGen Sequence Capture Arrays to uncover the genetic changes that are involved in the development of leukemia. The new sequence information will be linked to an existing extensive clinical and cytogenetic database to investigate the relationship between genetic change and the clinical features of this devastating disease. The researchers expect that the new data could have implications for the future therapy and clinical outcome of hematological malignancies.

New Map Reveals Dynamic Variation In Human Genome

A team of researchers led by Howard Hughes Medical Institute investigator Evan E. Eichler at the University of Washington has produced the first high-resolution map showing the structural variation that exists in the human genome. With the map, researchers can now begin to see how the underlying structure of one person's genome differs from that of another.

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