First glimpse of a key DNA repair protein at work: related news

First glimpse of a key DNA repair protein at work

Mre11 proteins initiate the repair of double-strand breaks in DNA either on two ends of broken DNA brought together (synaptic complex at left) or at the site of a collapsed fork in replicating DNA (branching complex at right). The detailed structural ...

Star Ocean: First Departure

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The gripping potential of DNA nanotechnology

(Nanowerk Spotlight) DNA, the fundamental building block of our genetic makeup, has become an intense nanotechnology research field. DNA molecules can serve as precisely controllable and programmable scaffolds for organizing functional nanomaterials in the design, fabrication, and characterization of nanometer scale electronic devices and sensors. The reason why DNA could be useful in nanotechnology for the design of electric circuits is the fact that it actually is the best nanowire in existence – it self-assembles, it self-replicates and it can adopt various states and conformations (see: DNA electronics in nanotechnology or The long road to molecular electronics could be paved with DNA). Then of course there is a rich body of work on DNA use in nanorobotics such as Ned Seeman's work at NYU (see: Nanorobotic arm to operate within DNA

The Gene Is Having an Identity Crisis

gollum123 writes "New large-scale studies of DNA are causing a rethinking of the very nature of genes. A typical gene is no longer conceived of as a single chunk of DNA encoding a single protein. It turns out, for example, that several different proteins may be produced from a single stretch of DNA. Most of the molecules produced from DNA may not even be proteins, but rather RNA. The familiar double helix of DNA no longer has a monopoly on heredity: other molecules clinging to DNA can produce striking differences between two organisms with the same genes — and those molecules can be inherited along with DNA. Scientists have been working on exploring the 98% of the genome not identified as the protein-coding region. One of the biggest of these projects is an effort called the Encyclopedia of DNA Elements, or 'Encode.

DNA Repair: Structure Of The Mre11 Protein Bound To DNA

Repairing breaks in the two strands of the DNA double helix is critical for avoiding cancer. In humans and other organisms, a molecular machine called the MRN complex is responsible for finding and signaling double-strand breaks (DSBs), then launching the error-free method of DNA repair called homologous recombination.

Photonic crystal biosensors detect protein-DNA interactions

Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitors of protein-nucleic acid and protein-protein interactions.

Photonic crystal biosensors detect protein-DNA interactions

Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitors of protein-nucleic acid and protein-protein interactions.

Photonic Crystal Biosensors Detect Protein-DNA Interactions

Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitors of protein-nucleic acid and protein-protein interactions.

Photonic crystal biosensors detect protein-DNA interactions

CHAMPAIGN, Ill. — Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitors of protein-nucleic acid and protein-protein interactions.

New Role For Critical DNA Repair Molecule In Immune System

The human immune system is a brilliantly adaptable weapon against foreign invaders. But it all depends on the work of specialized cells called lymphocytes that have made a risky evolutionary gambit to mutate their own DNA. New research published in Nature shows for the first time that a molecule devoted to DNA repair plays a broader role in this genetic reshuffling — called recombination — than scientists had thought.

How A Well-known Protein Repairs Broken DNA Ends

During the life cycle of our cells, a minefield of environmental and biological assaults can lead to double-stranded DNA breaks, the most lethal and dangerous form of DNA damage. Now, in research published online in Nature, Rockefeller University scientists reveal that when these breaks occur, a protein called 53BP1 helps repair them by mobilizing their dangly DNA ends — findings that uncover a previously unknown aspect of how double-stranded breaks can get fixed.

First Chicago Bancorp & First Chicago Bank & Trust Names J. Mikesell Thomas President and CEO, and a Director of the Company, and CEO of First Chicago Bank & Trust

First Chicago Bancorp & First Chicago Bank & Trust Names J. Mikesell Thomas President and CEO, and a Director of the Company, and CEO of First Chicago Bank & Trust

Structure Determination of Proteinâ'Protein Complexes Using NMR Chemical Shifts: Case of an Endonuclease Colicinâ'Immunity Protein Complex

Structure Determination of Protein−Protein Complexes Using NMR Chemical Shifts: Case of an Endonuclease Colicin−Immunity Protein Complex

Book Review of DNA Interactions with Polymers and Surfactants

The physical interactions of DNA with polymers and surfactants are of interest due to the potential benefits in biotechnology and the use of DNA as a building block in self-assembled structures. Although the book contains information about the characterization of cationic polymers and lipids as nonviral gene delivery vehicles, at its core it focuses primarily on the physical interaction and modeling of DNA with small molecules, polymers, surfactants, and with itself. In particular, this book begins with an investigation of DNA as a polyelectrolyte and a description of its biophysical properties in solution and as a single molecule. The interaction of DNA with surfactants, cationic polymers, and lipids is covered next, with the focus first being on single molecule models and then on interactions in solution.

DNA-Small Molecule Chimera with Responsive Protein-Binding Ability

In this communication, we disclose a generalizable strategy for developing agents with regulable protein-binding ability. In particular, a responsive DNA-small molecule chimera (DC) 1 consisting of two synthetic protein-binding arms and a core oligonucleotide (ODN) domain is discussed. DC 1 can be cycled from a bidentate intramolecular quadruplex form to a monodentate duplex structure, via addition of external ODN stimuli. Importantly, these distinct secondary structures of 1 lead to significantly different protein-binding abilities, with the bidentate conformation showing a 20-fold enhancement (with a 0.8 μM dissociation constant, K

New study bolsters beliefs about DNA repair

Aucott et al. report the first in vivo experiments on the heterochromatin protein 1 (HP1) family, which sidles up to silent DNA. The results, to be published in the Nov. 17 issue of the Journal of Cell Biology, add to the evidence that the different versions of the proteins help cells fix broken DNA.

EA Recommends Hilarious Work-Around For RA3 CD-key

sunderbear noted that EAs Command & Conquer 3 shipped missing the last digit of the CD Key. He writes "EA's brightest minds have put their synapses into overdrive in order to whip up a comical work-around. 'There is currently a work-around that may allow you to bypass this issue. Since you have the first 19 characters of the code already, you can basically try guessing the last character,' said a note on EA's customer support site. Yes, they're serious. 'To do this, simply enter your existing code, and then for the last character, try the letters A-Z, and then the numbers 0-9. You should eventually get the right combination, and be able to play the game.'" It appears that the helpful hint has been purged.

First Whole Cancer Genome Sequenced

dooling writes "A paper detailing the sequencing of the first human cancer genome will be published in the 6 November 2008 issue of Nature. This is not only the first cancer genome published, it is the first female genome as well. You can read the paper's abstract, DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome, or the story in Science News. This issue of Nature also has articles on the sequencing of the first African and Asian genomes. The sequencing in all three articles was done using the Illumina Genome Analyzer, one of the massively parallel, next-generation genome sequencing platforms."

Protein Shown To Play A Key Role In Normal Development Of Nervous System

A protein that enables nerve cells to communicate with each other plays a key role in controlling the developing nervous system. Research into how that protein helps precise connections to form among nerve cells may provide a basis for eventual treatments for patients who suffer injuries to their nervous system, including spinal cord injury.

2008 Horwitz Prize Awarded for Protein Folding, DNA Structure

PROTEIN FOLDING, DNA, ROSALIND FRANKLIN, ARTHUR HORWICH, ULRICH HARTL, ALZHEIMER’S DISEASE, HUNTINGTON’S DISEASE, CYSTIC FIBROSIS, HUMAN BIOLOGY, SHAPE, PROTEIN MISFOLDING, X-RAY CRYSTALLOGRAPHY, DOUBLE HELIX

Work With Fluorescent Jellyfish Protein Wins Nobel Prize in Chemistry

jellyfishThree researchers who worked on a fluorescent protein found in jellyfish and developed it into a standard laboratory tool have been awarded the Nobel Prize in chemistry, the prize committee announced today. The three researchers, Osamu Shimomura, Martin Chalfie, and Roger Tsien, worked separately to first isolate the protein, which glows brightly when exposed to ultraviolet light, and then to develop ways to use it as a luminescent marker in the cells of other organisms.

Tracking Down The Cause Of Mad Cow Disease: First Synthetic Prion Protein With An Anchor

The cause of diseases such as BSE in cattle and Creutzfeld–Jakob disease in humans is a prion protein. This protein attaches to cell membranes by way of an anchor made of sugar and lipid components (a glycosylphosphatidylinositol, GPI) anchor. The anchoring of the prions seems to have a strong influence on the transformation of the normal form of the protein into its pathogenic form, which causes scrapie and mad cow disease.

16:43 - Greece: Dresdner sees Euronank Q3 profits +3%; Funding, liquidity in focus

Exports FOB achieved in the first quarter of 2006 amounted to € 6212,6 million, by 21.9% more than in the first quarter of 2005.Value of exports to the European Union countries (EU-25), in the first quarter of 2006,as compared to the first quarter of 2005, increased by 18.8%. Weight of exports to the European Union countries in total exports was 68.5%, according to National Administration of Customs.Partner countries holding the first places for exports in the first quarter of 2006 (representing 74.7% of total exports) were the following: Italy (19.0% of total exports), Germany (15.2%), France (7.3%), Turkey (6.9%), Hungary (4.8%), United Kingdom (4.7%), U.S.A. (3.5%), Austria (3.2%), Bulgaria (3.0%), Spain (2.6%), United Arab Emirates (2.

16:23 - Greece: Deutsche Bank cuts Terna target; Sees benefits from GEK merger

Exports FOB achieved in the first quarter of 2006 amounted to € 6212,6 million, by 21.9% more than in the first quarter of 2005.Value of exports to the European Union countries (EU-25), in the first quarter of 2006,as compared to the first quarter of 2005, increased by 18.8%. Weight of exports to the European Union countries in total exports was 68.5%, according to National Administration of Customs.Partner countries holding the first places for exports in the first quarter of 2006 (representing 74.7% of total exports) were the following: Italy (19.0% of total exports), Germany (15.2%), France (7.3%), Turkey (6.9%), Hungary (4.8%), United Kingdom (4.7%), U.S.A. (3.5%), Austria (3.2%), Bulgaria (3.0%), Spain (2.6%), United Arab Emirates (2.

Sorenson Forensics to Provide Validation Services for Western Africa's First Forensic DNA Lab

Sorenson Forensics announced on September 22 that it has been awarded a contract by the Center for Diagnostics and Research in Molecular Medicine, a private clinical laboratory in Dakar, Republic of Senegal, which has the exclusive contract to provide forensic DNA testing and analysis for the Senegal government. Under the contract, Sorenson Forensics will assist the center in establishing what will be the first forensic DNA lab in western Africa and will provide ongoing support and laboratory validation.

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