Dividing cells find their middle by following a protein contour map: related news

Dividing Cells Find Their Middle By Following A Protein contour Map

Self-organization keeps schools of fish, flocks of birds and colonies of termites in sync. It’s also, according to new research, the way cells regulate the final stage of cell division. Scientists at Rockefeller University have shown that a protein-chemistry-based contour map, which helps individual proteins locate the center of their cell without direction from a “master organizer,� is key to ensuring accurate division during mitosis.

Dividing cells find their middle by following a protein 'contour map'

Self-organization keeps schools of fish, flocks of birds and colonies of termites in sync. It’s also, according to new research, the way cells regulate the final stage of cell division. Scientists at Rockefeller University have shown that a protein-chemistry-based contour map, which helps individual proteins locate the center of their cell without direction from a “master organizer,” is key to ensuring accurate division during mitosis.

Nanocantilevers image nanoparticles in cells

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Native Conformation at Specific Residues in Recombinant Inclusion Body Protein in Whole Cells Determined with Solid-State NMR Spectroscopy

Inclusion bodies are insoluble aggregates that are formed by bacteria to store excess recombinant protein produced during expression. The structure of the protein in inclusion bodies is poorly understood but it has been hypothesized that the protein may form misfolded β sheet aggregates. This paper presents an isotopic labeling and solid-state nuclear magnetic resonance approach to determine the secondary structure of individual residues within a recombinant influenza virus “FHA2� protein in inclusion bodies. The inclusion bodies were studied either in the context of the unlysed hydrated E. coli cells or in the hydrated pellet formed from centrifugation of the material insoluble in the cell lysate. The native structure of FHA2 is predominantly helical and native helical structure was also observed for several specific residues in the

Deconstructing Green Fluorescent Protein

Green fluorescent protein (GFP) has been reassembled from two pieces, a large fragment 214 amino acids in length that is produced recombinantly (GFP 1−10) and a short synthetic peptide corresponding to the 11th stave of the β-barrel that is 16 amino acids long (synthetic GFP 11), following a system developed by Waldo and co-workers (Cabantous, S.; et al. Nat. Biotechnol. 2005, 23, 102−7) as an in vivo probe for protein association and folding. We demonstrate that the reassembled protein has identical absorption and excited-state proton transfer dynamics as a whole protein of the identical sequence. We show that the reassembled protein can be taken apart and the peptide replaced with a different synthetic peptide designed to perturb the chromophore absorption.

Protein's role in stem cells fate studied

Notch protein in human embryonic stem cells helps cells decide their own fate, which may be useful in stem cell therapy development, U.S. researchers said.

Protein's role in stem cells fate studied

Baltimore -- Notch protein in human embryonic stem cells helps cells "decide" their own fate, which may be useful in stem cell therapy development, U.S. researchers said.

Protein's role in stem cells fate studied

BALTIMORE, July 22 (UPI) -- Notch protein in human embryonic stem cells helps cells "decide" their own fate, which may be useful in stem cell therapy development, U.S. researchers said.

Media Cybernetics Offers Free Image Processing Consultations

Researchers learn sophisticated image analysis techniques using their own images BETHESDA, Md.--(Business Wire)-- Media Cybernetics, the scientific imaging software company, has added an exciting, new tool to their website that enables individuals to upload their images and receive a free image processing consultation. This new image upload feature gives researchers the opportunity to describe their imaging challenge and receive feedback on how they can accomplish their desired outcome using image processing tools. This tool allows Media Cybernetics' representatives to consult with and train researchers-using their own images- resulting in a significantly reduced learning curve. Researchers benefit immediately, improving their research processes through the use of advanced image analysis techniques, including counting objects, tracking th

Etisalat's Online Services leaves positive impact on customers during the holiday season

Etisalat today announced that its online services continue to receive positive feedback from customers during the holiday season by helping them to conduct transactions at their own convenience even when they are on holiday abroad. Etisalat services allow customers to automatically pay their bills when it is due; renew their ‘Wasel’ balance automatically or manually through their mobile by dialing *122# , along with access to many other services that are available on www.etisalat.ae/online. Customers can easily manage their account through the online services; check the value and details of their bills, make payments online, recharge their ‘Wasel’ account and carry out many transactions quickly and safely at any time with one single click.

Farmers Recognised for Their Commitment to Wildlife ; East Yorks: Farmers Who Encourage Wildlife Have Been Recognised for Their Exceptional Efforts to Help Birds and Animals on Their Farms.

East Yorks: Farmers who encourage wildlife have been recognised for their exceptional efforts to help birds and animals on their farms.

Scientists Use Virus To Reprogram Adult Cells In Mice

n2hightech writes "Harvard University scientists figured out how to activate a trio of dormant genes that commanded non-insulin producing pancreas cells to switch to the Beta type insulin producing cells. The method uses an engineered virus to infect the cells and deliver special proteins that activate the dormant genes. This technology has the potential to make all stem cell based methods obsolete because it does not pose the risk of rejection and cancer associated with stem cells. A simple injection into the area where cells need to be reprogrammed is all that is required." Gospodin adds a link to coverage at the Washington Post.

Protein folding: terahertz absorption spectroscopy detects changes in protein-water network

(Nanowerk News) Water is no passive spectator of biological processes; it is an active participant. Protein folding is thus a self-organized process in which the actions of the solvent play a key role. So far, the emphasis in studies of protein folding processes has been on observation of the protein backbone and its side chains.

Identification of protein able to stimulate production of T-cells

A team of Canadian and Finnish scientists has identified a protein able to stimulate the production of T-cells, the white blood cells involved in the recognition and the elimination of infectious agents. The discovery by researchers of the Institute for Research in Immunology and Cancer (IRIC) at the Université de Montréal in Canada and the University of Oulu in Finland – published in the latest edition of the journal Immunity – could help to combat age-related declines in immune response.

Combating Age-related Immune-response Decline: Protein Found To Stimulate Production Of T-cells

A team of Canadian and Finnish scientists has identified a protein able to stimulate the production of T-cells, the white blood cells involved in the recognition and the elimination of infectious agents. The discovery by researchers of the Institute for Research in Immunology and Cancer (IRIC) at the Université de Montréal in Canada and the University of Oulu in Finland could help to combat age-related declines in immune response.

MapusoftMapuSofts Solutions Give Tecnobit the Ability to Move their Code to the Linux Operating System MapuSoft Technologies (MT) announced that Tecnobit, of Valdepeas, Spain has selected MTs OS Changer software reuse product for their current mig

MapuSoft Technologies (MT) announced that Tecnobit, of Valdepeñas, Spain has selected MT´s OS Changer software reuse product for their current migration project. Tecnobit is using OS Changer to move their legacy software to the Linux operating system. The application that uses OS Changer is a simulator of a navigation console for a tactical data system for the Spanish Armada. By implementing MT´s solution, and recycling their original software, Tecnobit will save valuable development resources and eliminate an expensive and time consuming code rewrite.

Subject to Change

prostoalex writes "Most companies would call themselves innovative and would claim they're delivering an above-average service to their customers. Yet, their customers opinions might differ. If you drill a company on their innovation practices, they would probably mention two approaches they employ: 1. Their research department meets with target groups, compiles presentations for the upper management, which then occasionally hands those reports over to the development department. 2. Their research or marketing department comes up with competitive matrix of the products available from competition. In a meeting then, executives see that their product is missing a feature, and hence the development department is assigned the task of adding 'an Internet-enabled installer' to the product, since everybody else offers them, thereby creating mark

Researchers Improve Solar Cell Performance

Vegematic writes "Researchers at MIT have improved solar collectors using dyes. They just increased their performance results by a factor of 4. These paint-on materials can increase the power obtained from existing solar cells by a factor of over 40 without needing to track the sun. 'By collecting light over their full surface and concentrating it at their edges, these devices reduce the required area of solar cells and consequently, the cost of solar power. Stacking multiple concentrators allows the optimization of solar cells at each wavelength, increasing the overall power output.' There is also a shorter FAQ available."

Injections To Replace Heart Surgery?

chareverie writes "Researchers at Harvard University have been working towards a goal of replacing some types of heart surgery with injections of cells that would grow into blood vessels for damaged hearts. The cells that would be used are progenitor cells obtained from the blood or bone marrow, as opposed to stem cells that are obtained from human embryos. The research team was successful with their tests on growing heart blood vessels in mice. Joyce Bishoff, an associate professor of medicine at Harvard and senior author of the report, says, 'Our next goal down the line is to use them in humans.' She also notes that more studies need to be done on animals to see how these cells would react and behave with other types of tissues. A similar human experiment was done two years ago in Germany, during which a few people from a group of 75 he

Study identifies mechanism linking stress to physical illness, aging

Every cell contains a tiny clock called a telomere, which shortens each time the cell divides. Short telomeres are linked to a range of human diseases, including HIV, osteoporosis, heart disease and aging. Previous studies have shown that an enzyme within the cell, called telomerase, keeps immune cells young by preserving their telomere length and ability to continue dividing. UCLA scientists found that the stress hormone cortisol suppresses immune cells' ability to activate their telomerase. This may explain why the cells of persons under chronic stress have shorter telomeres.

Like Eavesdropping At A Party: How A Tiny Protein Senses All The Communications In A Cell

Cells rely on calcium as a universal means of communication. For example, a sudden rush of calcium can trigger nerve cells to convey thoughts in the brain or cause a heart cell to beat. A longstanding mystery has been how cells and molecules manage to appropriately sense and respond to the variety of calcium fluctuations within cells.

Like Eavesdropping at a Party: Scientists Discover How a Tiny Protein Senses All the Communications in a Cell

Cells rely on calcium as a universal means of communication. For example, a sudden rush of calcium can trigger nerve cells to convey thoughts in the brain or cause a heart cell to beat. A longstanding mystery has been how cells and molecules manage to appropriately sense and respond to the variety of calcium fluctuations within cells.

Ronin An Alternate Control For Embryonic Stem Cells

Like the masterless samurai for whom it is named, the protein Ronin chooses an independent path, maintaining embryonic stem cells in their undifferentiated state and playing essential roles in genesis of embryos and their development, said Baylor College of Medicine researchers who reported on this novel cellular regulator in the current issue of the journal Cell.

Researchers Modify T-Cells, Make Them HIV Resistant

DieNadel writes to share that naturally occurring proteins called "zinc fingers" are being used in a new approach to AIDS treatment. Using modified T-Cells with the zinc fingers, researchers at the Pennsylvania School of Medicine have shown a reduction in viral load in mice. "'By inducing mutations in the CCR5 gene using zinc finger proteins, we've reduced the expression of CCR5 surface proteins on T cells, which is necessary for the AIDS virus to enter these immune system cells,' explains first author Elena Perez, MD, PhD, Assistant Professor of Pediatrics at Penn. 'This approach stops the AIDS virus from entering the T cells because it now has an introduced error into the CCR5 gene.'"

T-Mobile To Open App Store For All of Their Phones

tsa brings news that T-Mobile will be developing their own application store to compete with Apple's popular distribution scheme. Their aim is to be capable of bringing new services to all of their customers. Excerpting: "Developers will submit their applications online; the revenue-share agreement will be based on how much the application uses the network; and the applications will be presented to the user in order of popularity, not according to T-Mobile's preferences. It's all pretty straightforward, but the more interesting aspect is that this will apply to all the carrier's platforms from upcoming Android to Java to Sidekick and Windows Mobile."

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