Broken DNA Must Find Right Partners Quickly Amid Repairs: related news

Broken DNA Must Find Right Partners Quickly Amid Repairs

Just as square dance partners join hands at a particular point in the music, so broken pieces of DNA in our cells reunite as they are repaired. Precisely and quickly, these DNA pieces identify each other and tether together. A tumor-suppressor gene called ATM choreographs this fast-paced, but reliable, reassembly operation.

Broken DNA Must Find Right Partners Quickly Amid Repairs

A gene called ATM suppresses DNA break-induced chromosome translocations, which are present in some cancers and predict the success or failure of therapies for those cancers. The research, described in this week's issue of Nature, was performed at The University of Texas Health Science Center at San Antonio.

A global DNA barcode database

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Researchers show how DNA repairs may reshape the genome

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First DNA Molecule Constructed from Mostly Synthetic Components

ScienceDaily is reporting that Japanese chemists have created the world's first DNA molecule comprised of almost entirely artificial components. The breakthrough could lead to advances in both medicine and technology, possibly utilizing the massive storage capacity of DNA. "In the new study, Masahiko Inouye and colleagues point out that scientists have tried for years to develop artificial versions of DNA in order to extend its amazing information storage capabilities. As the genetic blueprint of all life forms, DNA uses the same set of four basic building blocks, known as bases, to code for a variety of proteins used in cell functioning and development. Until now, scientists have only been able to craft DNA molecules with one or a few artificial parts, including certain bases.

DNA Heritage Success in Patent Battle Helps Keep Genealogy DNA Test Prices Low

PRNewswire/ -- DNA Heritage has recently overcome patent claims held by a competitor which would have severely restricted the use of DNA testing and databases that allow families around the world to match and connect up through their DNA. The patent covers the use of surnames and Y-chromosomes to establish a family connection. The UK Intellectual Property Office (UK IPO) has now rendered a formal opinion stating that the relevant claims are all invalid.

DNA Heritage Success in Patent Battle Helps Keep Genealogy DNA Test Prices Low

RICHMOND, Texas, July 30 /PRNewswire/ -- DNA Heritage has recently overcome patent claims held by a competitor which would have severely restricted the use of DNA testing and databases that allow families around the world to match and connect up through their DNA. The patent covers the use of surnames and Y-chromosomes to establish a family connection. The UK Intellectual Property Office (UK IPO) has now rendered a formal opinion stating that the relevant claims are all invalid.

Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini

We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5′- and 3′-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

New electrostatic-based DNA microarray technique could revolutionize medical diagnostics

A new method for reading DNA (or RNA) microarrays is based on measuring the electrostatic repulsion between silica microspheres and hybridized DNA. Surface areas containing double-stranded DNA (red) or single-stranded DNA (blue) can be easily disting ...

DNA Sewing Machine Manipulates Delicate DNA Chains Without Breaking Them

Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The new work demonstrates a unique way to manipulate delicate DNA chains without breaking them.

Modified DNA helps scientists understand secrets of DNA repair mechanisms

(Nanowerk News) A modified DNA is helping scientists to understand the sophisticated DNA repair mechanisms that allow dormant bacteria to come 'back to life'.

Electron Transport by Molecular Motion of redox-DNA Strands: Unexpectedly Slow Rotational Dynamics of 20-mer ds-DNA Chains End-Grafted onto Surfaces via C6 Linkers

Electron Transport by Molecular Motion of redox-DNA Strands: Unexpectedly Slow Rotational Dynamics of 20-mer ds-DNA Chains End-Grafted onto Surfaces via C

Bacteria In Extremely Hostile Environments: New Protein Discovered That Repairs DNA Under Extreme Conditions

Mild environmental conditions are a prerequisite for life. Strong acids or dissolved metallic salts in high concentrations are detrimental to both humans and to simpler life forms, such as bacteria. Such conditions destroy proteins, ensuring that all biological functions in the cells come to a standstill. So what do we find at the limits of hostile conditions where we still find life?

DNA sewing machine

(Nanowerk News) Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The work published in the Royal Society of Chemistry journal Lab on a Chip demonstrates a unique way to manipulate delicate DNA chains without breaking them ("On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures" – free access article).

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Miniaturized DNA Sewing Machines

Roland Piquepaille writes "Japanese researchers have found a way to build long threads of DNA using miniaturized hooks and bobbins. In fact, they've demonstrated how to manipulate delicate DNA chains without breaking them. They've designed these laser-directed microdevices to pick up and manipulate individual molecules of DNA. The scientists have used optical tweezers to catch and move these microdevices, which could be used in the future to detect genetic disorders such as Down's syndrome." Here's a link to the journal article.

Researchers Discover New DNA Binding Activity of E. coli Protein

Northeastern University scientists have discovered a new and unique DNA binding property of a protein in E. coli. Penny J. Beuning, Assistant Professor in the Department of Chemistry and Chemical Biology, spent the last two years researching double and single-stranded DNA binding of E. coli DNA polymerase III alpha protein and notes that her findings have potential for developing a new antibacterial target.

ARTIST'S RESALE RIGHT

That this House congratulates the Government on successfully introducing the Artist's Resale Right in 2006; notes that under the new right the Design and Artists Copyright Service has so far collected more than £5.2 million on behalf of more than 1,500 artists, who have now received royalties with an average payment of £501 per work of art; believes this has strengthened the flourishing British art market by supporting struggling artists; and considers that the right should be extended to the estates of deceased artists as soon as possible without extending the current derogation beyond 2010.

Launch Pad Repairs to Begin; Hubble Repair Mission Should Go As Scheduled

Work will begin on Friday to repair damaged sections of Kennedy Space Center’s launch pad 39A that was damaged during the last space shuttle launch on May 31. On Thursday, (June 26) NASA managers approved a plan that would complete the repairs by the third week of August. Therefore the mission schedule shouldn’t be impacted. The next space shuttle flight, the high-profile final mission to repair the Hubble Space Telescope is scheduled to launch on October 8, and if all goes well with the repairs, space shuttle Atlantis would crawl its way out to the pad on August 29. "We really like the plan," said shuttle Program Manager John Shannon. "We expect to start moving out on it right away."

Tricks of DNA Repair

Duke University Medical Center and NIH researchers have found that repeat-associated double-strand breaks can reshape the genome. In watching how DNA repairs itself in yeast after being broken by radiation, the scientists found a high level of recombination in repeated regions of the genome. "We have been able to show with yeast that these repeated sequences allow the formation of new types of chromosomes (chromosome aberrations), and represent one important way of diversifying the genome," says Lucas Argueso at ScienceDaily.

DNA tests find stolen baby in Guatemala

DNA tests for the first time have confirmed that a baby was stolen from her mother and adopted for profit in Guatemala.

Researchers Find Link Between DNA Palindromes and Disease

Long DNA sequences, or palindromes, change the shape of the molecule from double helix to hairpin-like formation, which causes replication to stall. Altered or stalled replication causes chromosomal breaking, resulting in cancers and diseases.

How DNA Repairs Can Reshape Genome, Spawn New Species

Researchers at Duke University Medical Center and at the National Institute of Environmental Health Sciences (NIEHS) have shown how broken sections of chromosomes can recombine to change genomes and spawn new species.

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